Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2443..3124 Replicon plasmid p9b2
Accession NZ_CP061371
Organism Komagataeibacter rhaeticus strain ENS9b

Toxin (Protein)


Gene name vapC Uniprot ID A0A7H4IM06
Locus tag ICJ78_RS16895 Protein ID WP_007396297.1
Coordinates 2702..3124 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID W5YD93
Locus tag ICJ78_RS16890 Protein ID WP_010512461.1
Coordinates 2443..2637 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICJ78_RS16875 77..778 - 702 Protein_0 Fic family protein -
ICJ78_RS16880 1093..1761 - 669 WP_025439951.1 hypothetical protein -
ICJ78_RS16885 2054..2446 - 393 WP_007396299.1 PIN domain nuclease -
ICJ78_RS16890 2443..2637 - 195 WP_010512461.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ICJ78_RS16895 2702..3124 - 423 WP_007396297.1 type II toxin-antitoxin system VapC family toxin Toxin
ICJ78_RS16900 3121..3372 - 252 WP_039733231.1 plasmid stabilization protein -
ICJ78_RS16905 3459..3722 - 264 WP_007396295.1 toxin-antitoxin system HicB family antitoxin -
ICJ78_RS16910 3719..4141 - 423 WP_007396294.1 putative toxin-antitoxin system toxin component, PIN family -
ICJ78_RS16915 4188..7565 - 3378 WP_166498088.1 Ti-type conjugative transfer relaxase TraA -
ICJ78_RS16920 7662..8021 + 360 WP_191011408.1 conjugal transfer protein TraD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..13375 13375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-47)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15283.53 Da        Isoelectric Point: 5.2273

>T172509 WP_007396297.1 NZ_CP061371:c3124-2702 [Komagataeibacter rhaeticus]
MILLDTNVISEPWKPVPEQRVLAWIDGQAIETLFLSAVTVAELRFGIGAMPSGRRRSVLHERLEQEVLPLFAGRVLSFDL
AASQAYAELMVRARSEGRAIGKADGYIAATAASRGYVVASRDVSPFEAAGVRVLNPWEDT

Download         Length: 423 bp

>T172509 NZ_CP079772:1550124-1550231 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7268.49 Da        Isoelectric Point: 10.4776

>AT172509 WP_010512461.1 NZ_CP061371:c2637-2443 [Komagataeibacter rhaeticus]
MRTNIIIDDALMTDALKASGVKTKKEAVELGLRTLIRLKQQRELRTLRGKLDWQGDLDAMRSDA

Download         Length: 195 bp

>AT172509 NZ_CP079772:c1550077-1550011 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4IM06

Antitoxin

Source ID Structure
AlphaFold DB A0A318QDR0

References