Detailed information of TA system TA172506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3352398..3353004
• Replicon: chromosome
• Accession: NZ_CP061369
• Organism: Komagataeibacter rhaeticus strain ENS9b

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0D6QDX8
• Locus tag: ICJ78_RS15405
• Protein ID: WP_019087453.1
• Coordinates: 3352825..3353004 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A181CEU7
• Locus tag: ICJ78_RS15400
• Protein ID: WP_061275760.1
• Coordinates: 3352398..3352814 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICJ78_RS15360	3347933..3349126	-	1194	WP_025439978.1	Fic family protein	-
ICJ78_RS15365	3349587..3350090	+	504	WP_112209709.1	MucR family transcriptional regulator	-
ICJ78_RS15370	3350120..3350635	-	516	WP_112209721.1	hypothetical protein	-
ICJ78_RS15375	3350541..3350858	-	318	WP_158551941.1	hypothetical protein	-
ICJ78_RS15380	3351060..3351230	+	171	WP_191011453.1	hypothetical protein	-
ICJ78_RS15385	3351208..3351630	-	423	WP_112209708.1	type II toxin-antitoxin system VapC family toxin	-
ICJ78_RS15390	3351627..3351884	-	258	WP_112209707.1	plasmid stabilization protein	-
ICJ78_RS15395	3352067..3352321	-	255	WP_112209706.1	hypothetical protein	-
ICJ78_RS15400	3352398..3352814	-	417	WP_061275760.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ICJ78_RS15405	3352825..3353004	-	180	WP_019087453.1	type II toxin-antitoxin system HicA family toxin	Toxin
ICJ78_RS15415	3354737..3355159	-	423	WP_112209712.1	hypothetical protein	-
ICJ78_RS15420	3355156..3355351	-	196	Protein_3031	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ICJ78_RS15425	3356224..3357174	-	951	WP_112209711.1	replication initiator protein A	-
ICJ78_RS15430	3357171..3357488	-	318	WP_083824336.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3212035..3467854	255819

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-125)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6479.65 Da
• Isoelectric Point: 11.4111

>T172506 WP_019087453.1 NZ_CP061369:c3353004-3352825 [Komagataeibacter rhaeticus]
MKSADLIRELEKAGWKLDRVRGSHNVFKHPSRPGIVVVPHPKKDLGTGLVAAIRKQAGL

Nucleotide

• Length: 180 bp

>T172506 NZ_CP079772:c1317660-1317484 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 14827.67 Da
• Isoelectric Point: 4.3147

>AT172506 WP_061275760.1 NZ_CP061369:c3352814-3352398 [Komagataeibacter rhaeticus]
MRYPVVIERGSEATAFGVVFPDLPGCFSAGDTLDEAISNAEEAAAAWIDATLDAGEAVPSPSTLDAIQNNPDYEGWTVGF
VTIDPAVLDDRVERANISLPRRVLERLDALARSSHESRSGMIAAMTLQARLKPVVRSK

Nucleotide

• Length: 417 bp

>AT172506 NZ_CP079772:c1317438-1317022 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0D6QDX8

Antitoxin

• AlphaFold DB: A0A181CEU7