Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 427702..428302 Replicon chromosome
Accession NZ_CP061369
Organism Komagataeibacter rhaeticus strain ENS9b

Toxin (Protein)


Gene name relE Uniprot ID F7VHK4
Locus tag ICJ78_RS02125 Protein ID WP_006559873.1
Coordinates 427958..428302 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5YEQ9
Locus tag ICJ78_RS02120 Protein ID WP_010511780.1
Coordinates 427702..427965 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICJ78_RS02085 423110..424131 - 1022 Protein_406 IS110 family transposase -
ICJ78_RS02090 424471..424659 - 189 WP_112209847.1 hypothetical protein -
ICJ78_RS02095 424740..425297 + 558 WP_112209845.1 phosphate-starvation-inducible PsiE family protein -
ICJ78_RS02100 425763..426245 - 483 WP_112210156.1 Hsp20 family protein -
ICJ78_RS02105 426281..426562 - 282 WP_112209841.1 hypothetical protein -
ICJ78_RS02110 426561..426824 + 264 WP_102324447.1 YXWGXW repeat-containing protein -
ICJ78_RS02115 427345..427593 + 249 WP_010511782.1 hypothetical protein -
ICJ78_RS02120 427702..427965 + 264 WP_010511780.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ICJ78_RS02125 427958..428302 + 345 WP_006559873.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ICJ78_RS02130 428577..428999 + 423 WP_166498090.1 hypothetical protein -
ICJ78_RS02135 429027..431243 + 2217 WP_166498091.1 EAL domain-containing protein -
ICJ78_RS02140 431480..432236 + 757 WP_166498092.1 IS5 family transposase -
ICJ78_RS02145 432577..433218 + 642 WP_166498093.1 invasion associated locus B family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 395396..550306 154910
- flank IS/Tn - - 422459..422773 314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13248.13 Da        Isoelectric Point: 9.9064

>T172504 WP_006559873.1 NZ_CP061369:427958-428302 [Komagataeibacter rhaeticus]
MTEYAIEFDDRALREWDGLDGSIRRKFEKKLEKLVLNPHSPGNELHGDLAGFYKIKLRQDGYRLVYQVVEQRIVIFVIAV
GRREDSEIYTTATGRIPETPADRIKQPSGKSRKR

Download         Length: 345 bp

>T172504 NZ_CP079772:1154729-1155016 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9629.04 Da        Isoelectric Point: 7.3200

>AT172504 WP_010511780.1 NZ_CP061369:427702-427965 [Komagataeibacter rhaeticus]
MSAVTFRVDDALKSAAVAKLSAHGLSLSDVLRDTLAYIAETGQPPVKRRLVTDEDARLIEIVRERLADPAPRHRMTLAEL
KARHPDD

Download         Length: 264 bp

>AT172504 NZ_CP079772:1154490-1154729 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A841QEQ1

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4J448

References