Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 407844..408525 | Replicon | chromosome |
Accession | NZ_CP061369 | ||
Organism | Komagataeibacter rhaeticus strain ENS9b |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A7H4IM06 |
Locus tag | ICJ78_RS01985 | Protein ID | WP_007396297.1 |
Coordinates | 407844..408266 (+) | Length | 141 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | W5YD93 |
Locus tag | ICJ78_RS01990 | Protein ID | WP_010512461.1 |
Coordinates | 408331..408525 (+) | Length | 65 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ICJ78_RS01960 | 402947..403306 | - | 360 | WP_191011408.1 | conjugal transfer protein TraD | - |
ICJ78_RS01965 | 403403..406780 | + | 3378 | WP_166498088.1 | Ti-type conjugative transfer relaxase TraA | - |
ICJ78_RS01970 | 406827..407249 | + | 423 | WP_007396294.1 | putative toxin-antitoxin system toxin component, PIN family | - |
ICJ78_RS01975 | 407246..407509 | + | 264 | WP_007396295.1 | toxin-antitoxin system HicB family antitoxin | - |
ICJ78_RS01980 | 407596..407847 | + | 252 | WP_039733231.1 | plasmid stabilization protein | - |
ICJ78_RS01985 | 407844..408266 | + | 423 | WP_007396297.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
ICJ78_RS01990 | 408331..408525 | + | 195 | WP_010512461.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
ICJ78_RS01995 | 408522..408914 | + | 393 | WP_007396299.1 | PIN domain nuclease | - |
ICJ78_RS02000 | 409207..409875 | + | 669 | WP_025439951.1 | hypothetical protein | - |
ICJ78_RS02005 | 410190..410891 | + | 702 | Protein_390 | Fic family protein | - |
ICJ78_RS02010 | 411000..411134 | + | 135 | Protein_391 | IS630 family transposase | - |
ICJ78_RS02015 | 411237..412196 | + | 960 | WP_039998279.1 | IS110 family transposase | - |
ICJ78_RS02020 | 412193..413245 | - | 1053 | WP_039998278.1 | replication initiator protein A | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | - | 395396..550306 | 154910 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 141 a.a. Molecular weight: 15283.53 Da Isoelectric Point: 5.2273
>T172503 WP_007396297.1 NZ_CP061369:407844-408266 [Komagataeibacter rhaeticus]
MILLDTNVISEPWKPVPEQRVLAWIDGQAIETLFLSAVTVAELRFGIGAMPSGRRRSVLHERLEQEVLPLFAGRVLSFDL
AASQAYAELMVRARSEGRAIGKADGYIAATAASRGYVVASRDVSPFEAAGVRVLNPWEDT
MILLDTNVISEPWKPVPEQRVLAWIDGQAIETLFLSAVTVAELRFGIGAMPSGRRRSVLHERLEQEVLPLFAGRVLSFDL
AASQAYAELMVRARSEGRAIGKADGYIAATAASRGYVVASRDVSPFEAAGVRVLNPWEDT
Download Length: 423 bp
>T172503 NZ_CP079772:859577-859680 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 65 a.a. Molecular weight: 7268.49 Da Isoelectric Point: 10.4776
>AT172503 WP_010512461.1 NZ_CP061369:408331-408525 [Komagataeibacter rhaeticus]
MRTNIIIDDALMTDALKASGVKTKKEAVELGLRTLIRLKQQRELRTLRGKLDWQGDLDAMRSDA
MRTNIIIDDALMTDALKASGVKTKKEAVELGLRTLIRLKQQRELRTLRGKLDWQGDLDAMRSDA
Download Length: 195 bp
>AT172503 NZ_CP079772:c859718-859447 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7H4IM06 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A318QDR0 |