Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 407596..408266 Replicon chromosome
Accession NZ_CP061369
Organism Komagataeibacter rhaeticus strain ENS9b

Toxin (Protein)


Gene name vapC Uniprot ID A0A7H4IM06
Locus tag ICJ78_RS01985 Protein ID WP_007396297.1
Coordinates 407844..408266 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0N1N5A1
Locus tag ICJ78_RS01980 Protein ID WP_039733231.1
Coordinates 407596..407847 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICJ78_RS01955 402616..402882 - 267 WP_053323887.1 conjugal transfer protein TraD -
ICJ78_RS01960 402947..403306 - 360 WP_191011408.1 conjugal transfer protein TraD -
ICJ78_RS01965 403403..406780 + 3378 WP_166498088.1 Ti-type conjugative transfer relaxase TraA -
ICJ78_RS01970 406827..407249 + 423 WP_007396294.1 putative toxin-antitoxin system toxin component, PIN family -
ICJ78_RS01975 407246..407509 + 264 WP_007396295.1 toxin-antitoxin system HicB family antitoxin -
ICJ78_RS01980 407596..407847 + 252 WP_039733231.1 plasmid stabilization protein Antitoxin
ICJ78_RS01985 407844..408266 + 423 WP_007396297.1 type II toxin-antitoxin system VapC family toxin Toxin
ICJ78_RS01990 408331..408525 + 195 WP_010512461.1 type II toxin-antitoxin system VapB family antitoxin -
ICJ78_RS01995 408522..408914 + 393 WP_007396299.1 PIN domain nuclease -
ICJ78_RS02000 409207..409875 + 669 WP_025439951.1 hypothetical protein -
ICJ78_RS02005 410190..410891 + 702 Protein_390 Fic family protein -
ICJ78_RS02010 411000..411134 + 135 Protein_391 IS630 family transposase -
ICJ78_RS02015 411237..412196 + 960 WP_039998279.1 IS110 family transposase -
ICJ78_RS02020 412193..413245 - 1053 WP_039998278.1 replication initiator protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 395396..550306 154910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15283.53 Da        Isoelectric Point: 5.2273

>T172502 WP_007396297.1 NZ_CP061369:407844-408266 [Komagataeibacter rhaeticus]
MILLDTNVISEPWKPVPEQRVLAWIDGQAIETLFLSAVTVAELRFGIGAMPSGRRRSVLHERLEQEVLPLFAGRVLSFDL
AASQAYAELMVRARSEGRAIGKADGYIAATAASRGYVVASRDVSPFEAAGVRVLNPWEDT

Download         Length: 423 bp

>T172502 NZ_CP079772:676205-676459 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9079.36 Da        Isoelectric Point: 6.4584

>AT172502 WP_039733231.1 NZ_CP061369:407596-407847 [Komagataeibacter rhaeticus]
MSSVVIRNLPEETHRALKAQAMLHGRSTEAEIRTILEAAVRPPQRVRLGSLLASIGREAGVCDQDIAALQSRDQTPAEPM
SFE

Download         Length: 252 bp

>AT172502 NZ_CP079772:675957-676208 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4IM06

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1N5A1

References