Detailed information of TA system TA172501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 3801568..3801980
• Replicon: chromosome
• Accession: NZ_CP061368
• Organism: Wenzhouxiangella sp. AB-CW3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IC757_RS16430
• Protein ID: WP_190975353.1
• Coordinates: 3801792..3801980 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IC757_RS16425
• Protein ID: WP_190975352.1
• Coordinates: 3801568..3801783 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC757_RS16410	3796645..3797982	-	1338	WP_190975349.1	group II intron reverse transcriptase/maturase	-
IC757_RS16415	3798463..3799245	-	783	WP_190975350.1	class D beta-lactamase	-
IC757_RS16420	3799736..3801073	-	1338	WP_190975351.1	group II intron reverse transcriptase/maturase	-
IC757_RS16425	3801568..3801783	-	216	WP_190975352.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IC757_RS16430	3801792..3801980	-	189	WP_190975353.1	type II toxin-antitoxin system HicA family toxin	Toxin
IC757_RS16435	3802478..3803647	-	1170	WP_190974041.1	IS4 family transposase	-
IC757_RS16440	3803976..3805387	-	1412	Protein_3233	group II intron reverse transcriptase/maturase	-
IC757_RS16445	3805953..3806903	+	951	WP_190975343.1	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3802478..3803647	1169
	-	inside	Integron	-	-	3789861..3802102	12241

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-66)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6968.17 Da
• Isoelectric Point: 11.5470

>T172501 WP_190975353.1 NZ_CP061368:c3801980-3801792 [Wenzhouxiangella sp. AB-CW3]
MKVKELIKLLKQDGWYQARQRGSHRQFRHPVKSGTVTVSGKPNVDMPPGTLNNALKQAGLKK

Nucleotide

• Length: 189 bp

>T172501 NZ_CP079772:675957-676208 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7702.58 Da
• Isoelectric Point: 3.9207

>AT172501 WP_190975352.1 NZ_CP061368:c3801783-3801568 [Wenzhouxiangella sp. AB-CW3]
MQYVVILEEGPESWGAYVPDLPGCVAAGETREEALELIREAIEFHLEGMKEAGDAIPEPHSHSDVVQVNAA

Nucleotide

• Length: 216 bp

>AT172501 NZ_CP079772:676205-676459 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA