Detailed information of TA system TA172498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2245900..2247578
• Replicon: chromosome
• Accession: NZ_CP061368
• Organism: Wenzhouxiangella sp. AB-CW3

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: -
• Locus tag: IC757_RS09785
• Protein ID: WP_190974136.1
• Coordinates: 2245900..2247225 (-)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: IC757_RS09790
• Protein ID: WP_190974137.1
• Coordinates: 2247222..2247578 (-)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC757_RS09770	2241902..2243155	-	1254	WP_190974133.1	glutamate-5-semialdehyde dehydrogenase	-
IC757_RS09775	2243363..2244499	-	1137	WP_190974134.1	glutamate 5-kinase	-
IC757_RS09780	2244530..2245816	-	1287	WP_190974135.1	cardiolipin synthase B	-
IC757_RS09785	2245900..2247225	-	1326	WP_190974136.1	type II toxin-antitoxin system HipA family toxin	Toxin
IC757_RS09790	2247222..2247578	-	357	WP_190974137.1	helix-turn-helix domain-containing protein	Antitoxin
IC757_RS09795	2247711..2249321	-	1611	WP_190974138.1	amidohydrolase family protein	-
IC757_RS09800	2249500..2249958	+	459	WP_190974139.1	hypothetical protein	-
IC757_RS09805	2249955..2250251	+	297	WP_190974140.1	transcriptional regulator	-
IC757_RS09810	2250316..2251986	+	1671	WP_190974141.1	urocanate hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (170-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-68)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 49447.77 Da
• Isoelectric Point: 6.3932

>T172498 WP_190974136.1 NZ_CP061368:c2247225-2245900 [Wenzhouxiangella sp. AB-CW3]
VSTVAEVRLWGRTIGAVALMDGEQTAVFEYAPAFIGSGIEVAPLTMPLSDRVFRFPELSRQTFHGLPGLLADSLPDKFGH
LLINAWLARQGRSPGSMNAVERLCYTGRRGMGALEFEPRLGPKARESRHLEVDALVELASEVLSQRDELQASFGEDTSEQ
AMADILRVGTSAGGARAKAVVAWNPETGEVRSGQVDHGAGFEHWLLKFDGVSGNRDRELDDPQGYGAIEYAYHLMAVDAG
IEMTECRLLEENGRRHFMTRRFDRTSDGGKLHMQSLCAMAHFDYNLPGAYSYEQAFQIMRQLGLSMSELEQFYRRAVFNI
LGRNQDDHVKNIAFLMDRHGQWRLSPVFDLVFSYNPEGDWTARHQMTLNGRRDHFSFDDFRSLAAAAGLKRGRERLIFNE
VRSCLLDWPHYASRAGLPAATARRIEQLLRAEDVSPGKSGY

Nucleotide

• Length: 1326 bp

>T172498 NZ_CP079770:4233807-4234184 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAGCTTATTGCAATTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCAGGCATGTC
AGATTCGGGAAGAGCTGAGGCTATTATCGGGAGAGTCCAGGCCAGAGTTGCATATGAAGAGATTACCGGCCTTTTCGAAG
TCTCCGCAACTTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
TTGTTATTTCTGCGCCGTAACGGTGTGCAGGTATATGATTCACCAGAACTGGCAGAGCTTACTGTGGGGGCTGCGACCGG
AGAGGTATCCGTATCTACTGTCGTTGCCACGTTACGTAGATTGTATGGTACGGCGTAG

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13137.20 Da
• Isoelectric Point: 10.6984

>AT172498 WP_190974137.1 NZ_CP061368:c2247578-2247222 [Wenzhouxiangella sp. AB-CW3]
MSIANTMSDEAVLAELGRRLAQRRLALRLSQAELAERAGVGKRTVERIEAGQSAQMTSVVRLLRVLELMPALDAMIPAET
VRPMTLLKQGGKLPQRVRKRDDEQQVREAGSWAWGESE

Nucleotide

• Length: 357 bp

>AT172498 NZ_CP079770:4233586-4233807 [Escherichia coli]
ATGCAATCTATTAACTTCCGTACCGCACGCAGCAATCTTACCGAAGTGCTCAACAATGTTGAAGCCGGAGAAGAGGTTGA
AATCACCCGTAGAGGTCGTGAGCCAGCTGTAATTGTCAGCAAGGCCACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTCGCATCCCTGTTTGACACTCTGGACACCACCAATAAGAAACTGGTTAACCGATAA