Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 874513..875180 Replicon chromosome
Accession NZ_CP061368
Organism Wenzhouxiangella sp. AB-CW3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IC757_RS03690 Protein ID WP_190976041.1
Coordinates 874513..874941 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IC757_RS03695 Protein ID WP_190976042.1
Coordinates 874938..875180 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC757_RS03665 869742..870323 + 582 WP_190976036.1 hypothetical protein -
IC757_RS03670 870391..871548 - 1158 WP_190976037.1 hypothetical protein -
IC757_RS03675 871623..872312 - 690 WP_190976038.1 helix-turn-helix domain-containing protein -
IC757_RS03680 872503..873384 - 882 WP_190976039.1 hypothetical protein -
IC757_RS03685 873524..874501 - 978 WP_190976040.1 arsenic resistance protein -
IC757_RS03690 874513..874941 - 429 WP_190976041.1 type II toxin-antitoxin system VapC family toxin Toxin
IC757_RS03695 874938..875180 - 243 WP_190976042.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IC757_RS03700 875236..876219 - 984 WP_190976043.1 NAD(+) diphosphatase -
IC757_RS03705 876264..877946 - 1683 WP_190976044.1 hypothetical protein -
IC757_RS03710 878048..879091 - 1044 WP_190976045.1 tetratricopeptide repeat protein -
IC757_RS03715 879316..879528 + 213 Protein_733 PQQ-dependent sugar dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-127)

Antitoxin

SpoVT-AbrB domain

(11-52)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15610.78 Da        Isoelectric Point: 6.1333

>T172494 WP_190976041.1 NZ_CP061368:c874941-874513 [Wenzhouxiangella sp. AB-CW3]
VSSRFRYLLDTNIISDLVRHPQGPVAHRISELGEDTVCTSIVVSAELRYGAAKSGSEKLAHRVELLLSALEILPLESPAD
HHYAELRDHLTRQGTLIGPNDLLIAAHALAMGMTIVTANEREFLRVPGLGVENWLPGSDRDR

Download         Length: 429 bp

>T172494 NZ_CP079770:c4049618-4049154 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9149.39 Da        Isoelectric Point: 4.2597

>AT172494 WP_190976042.1 NZ_CP061368:c875180-874938 [Wenzhouxiangella sp. AB-CW3]
MTTSERQVRLFRNGRNQALRIPREFELEGDEAILHKEGDRLIIEPVRKGKLLALLASLEPLDVPFPDVDEDLPELDDDAL

Download         Length: 243 bp

>AT172494 NZ_CP079770:c4049953-4049618 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References