Detailed information of TA system TA172492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 183793..184295
• Replicon: chromosome
• Accession: NZ_CP061368
• Organism: Wenzhouxiangella sp. AB-CW3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IC757_RS00815
• Protein ID: WP_190975522.1
• Coordinates: 183793..184047 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IC757_RS00820
• Protein ID: WP_190975523.1
• Coordinates: 184044..184295 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC757_RS00785	178869..179171	-	303	WP_190975517.1	HigA family addiction module antidote protein	-
IC757_RS00790	179171..179461	-	291	WP_190975518.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IC757_RS00795	179657..180130	+	474	WP_190976887.1	DUF4442 domain-containing protein	-
IC757_RS00800	180093..181340	-	1248	WP_190975519.1	alpha/beta fold hydrolase	-
IC757_RS00805	181483..182472	+	990	WP_190975520.1	zinc-dependent alcohol dehydrogenase family protein	-
IC757_RS00810	182747..183760	+	1014	WP_190975521.1	NAD(P)-dependent alcohol dehydrogenase	-
IC757_RS00815	183793..184047	-	255	WP_190975522.1	Txe/YoeB family addiction module toxin	Toxin
IC757_RS00820	184044..184295	-	252	WP_190975523.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
IC757_RS00825	184506..184973	+	468	WP_190975524.1	hypothetical protein	-
IC757_RS00830	184970..186592	+	1623	WP_190975525.1	SWIM zinc finger family protein	-
IC757_RS00835	186602..187099	-	498	WP_190975526.1	exonuclease	-
IC757_RS00840	187292..188626	-	1335	WP_190976888.1	type II toxin-antitoxin system HipA family toxin	-
IC757_RS00845	188616..188948	-	333	WP_190975527.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10065.71 Da
• Isoelectric Point: 10.5637

>T172492 WP_190975522.1 NZ_CP061368:c184047-183793 [Wenzhouxiangella sp. AB-CW3]
VKICFHAHAWADYLYWQKADPKKLKRINELIRAIGRDPFKGVGKPEPLRGNWSGFWSRRIDRKHRLVYAVENDTLLIAQC
RFHY

Nucleotide

• Length: 255 bp

>T172492 NZ_CP079770:c3008378-3008205 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9288.40 Da
• Isoelectric Point: 4.6128

>AT172492 WP_190975523.1 NZ_CP061368:c184295-184044 [Wenzhouxiangella sp. AB-CW3]
MSTISYTDLRRRLASAMDQVNEDHAPLYITRQKGKGAVLLSADDYASIEETLYLMSSPRNAARLTEAIEGLRQGEGETRE
LIE

Nucleotide

• Length: 252 bp

>AT172492 NZ_CP079770:c3008702-3008406 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG