Detailed information of TA system TA172480

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3251916..3252400
• Replicon: chromosome
• Accession: NZ_CP061367
• Organism: Shigella sonnei strain 6207

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A377EAU1
• Locus tag: IC759_RS17235
• Protein ID: WP_014334020.1
• Coordinates: 3252110..3252400 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A376K4R9
• Locus tag: IC759_RS17230
• Protein ID: WP_005142544.1
• Coordinates: 3251916..3252110 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC759_RS17190 (3247111)	3247111..3247467	-	357	WP_005140877.1	hypothetical protein	-
IC759_RS17195 (3247525)	3247525..3247947	-	423	WP_001151171.1	DUF977 family protein	-
IC759_RS17200 (3247963)	3247963..3248688	-	726	WP_000450631.1	DUF1627 domain-containing protein	-
IC759_RS17205 (3248710)	3248710..3249456	-	747	WP_000788740.1	ATP-binding protein	-
IC759_RS17210 (3249463)	3249463..3250527	-	1065	WP_001262380.1	hypothetical protein	-
IC759_RS17215 (3250599)	3250599..3251024	-	426	WP_000693826.1	toxin YdaT family protein	-
IC759_RS17220 (3251021)	3251021..3251284	-	264	WP_001048456.1	helix-turn-helix transcriptional regulator	-
IC759_RS17225 (3251411)	3251411..3251896	+	486	WP_053002468.1	helix-turn-helix domain-containing protein	-
IC759_RS17230 (3251916)	3251916..3252110	+	195	WP_005142544.1	hypothetical protein	Antitoxin
IC759_RS17235 (3252110)	3252110..3252400	+	291	WP_014334020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IC759_RS17240 (3252679)	3252679..3252831	+	153	WP_000379558.1	DUF1391 family protein	-
IC759_RS17245 (3252843)	3252843..3253208	+	366	WP_024174355.1	hypothetical protein	-
IC759_RS17255 (3254110)	3254110..3254205	+	96	Protein_3201	transcriptional regulator	-
IC759_RS17260 (3254216)	3254216..3254404	+	189	WP_000449206.1	cell division inhibition protein DicB	-
IC759_RS17265 (3254401)	3254401..3254592	+	192	WP_001090204.1	DUF1482 family protein	-
IC759_RS17270 (3254686)	3254686..3255744	+	1059	Protein_3204	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3245064..3272166	27102

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11062.93 Da
• Isoelectric Point: 10.2013

>T172480 WP_014334020.1 NZ_CP061367:3252110-3252400 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Nucleotide

• Length: 291 bp

>T172480 NZ_CP061367:3252110-3252400 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7097.98 Da
• Isoelectric Point: 4.1759

>AT172480 WP_005142544.1 NZ_CP061367:3251916-3252110 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Nucleotide

• Length: 195 bp

>AT172480 NZ_CP061367:3251916-3252110 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Structures

Toxin

• AlphaFold DB: A0A377EAU1

Antitoxin

• AlphaFold DB: A0A376K4R9