Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1094551..1095179 Replicon chromosome
Accession NZ_CP061367
Organism Shigella sonnei strain 6207

Toxin (Protein)


Gene name hicA Uniprot ID A0A827WKV6
Locus tag IC759_RS06190 Protein ID WP_001259380.1
Coordinates 1094551..1094823 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag IC759_RS06195 Protein ID WP_000593555.1
Coordinates 1094820..1095179 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC759_RS06175 (1089555) 1089555..1090622 + 1068 WP_000361520.1 HlyD family secretion protein -
IC759_RS06180 (1090619) 1090619..1093354 + 2736 WP_000149089.1 ribosome-associated ATPase/putative transporter RbbA -
IC759_RS06185 (1093354) 1093354..1094478 + 1125 WP_005140446.1 ABC transporter permease -
IC759_RS06190 (1094551) 1094551..1094823 + 273 WP_001259380.1 type II toxin-antitoxin system HicA family toxin Toxin
IC759_RS06195 (1094820) 1094820..1095179 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IC759_RS06200 (1095299) 1095299..1095700 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
IC759_RS06205 (1095706) 1095706..1096512 - 807 WP_000173703.1 nickel import ATP-binding protein NikE -
IC759_RS06210 (1096509) 1096509..1097273 - 765 WP_001136223.1 nickel import ATP-binding protein NikD -
IC759_RS06215 (1097273) 1097273..1098106 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
IC759_RS06220 (1098103) 1098103..1099047 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1087567..1095700 8133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(29-79)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10071.81 Da        Isoelectric Point: 10.7076

>T172474 WP_001259380.1 NZ_CP061367:1094551-1094823 [Shigella sonnei]
MRTKVQALRKKKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVR
DWLLSIGVKP

Download         Length: 273 bp

>T172474 NZ_CP079767:4141532-4141909 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCGGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGGCATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT172474 WP_000593555.1 NZ_CP061367:1094820-1095179 [Shigella sonnei]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT172474 NZ_CP079767:4141074-4141442 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAAGACAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCCTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A827WKV6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References