172466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4741261..4741918 Replicon chromosome
Accession NZ_CP061350
Organism Klebsiella pneumoniae strain ENT1988

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ICN80_RS22765 Protein ID WP_002916310.1
Coordinates 4741261..4741671 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ICN80_RS22770 Protein ID WP_002916312.1
Coordinates 4741652..4741918 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICN80_RS22745 4737261..4738994 - 1734 WP_149998853.1 single-stranded-DNA-specific exonuclease RecJ -
ICN80_RS22750 4739000..4739713 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ICN80_RS22755 4739736..4740632 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ICN80_RS22760 4740733..4741254 + 522 WP_002916308.1 flavodoxin FldB -
ICN80_RS22765 4741261..4741671 - 411 WP_002916310.1 protein YgfX Toxin
ICN80_RS22770 4741652..4741918 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ICN80_RS22775 4742164..4743147 + 984 WP_022615657.1 tRNA-modifying protein YgfZ -
ICN80_RS22780 4743298..4743957 - 660 WP_002916317.1 hemolysin III family protein -
ICN80_RS22785 4744121..4744432 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
ICN80_RS22790 4744481..4745209 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ICN80_RS22795 4745328..4746761 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T172466 WP_002916310.1 NZ_CP061350:c4741671-4741261 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T172466 NZ_CP079767:2296956-2297174 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT172466 WP_002916312.1 NZ_CP061350:c4741918-4741652 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT172466 NZ_CP079767:2296556-2296930 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References