172455

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1578733..1579352 Replicon chromosome
Accession NZ_CP061350
Organism Klebsiella pneumoniae strain ENT1988

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ICN80_RS07540 Protein ID WP_002892050.1
Coordinates 1578733..1578951 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag ICN80_RS07545 Protein ID WP_002892066.1
Coordinates 1578978..1579352 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICN80_RS07505 1574780..1575043 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
ICN80_RS07510 1575043..1575183 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
ICN80_RS07515 1575180..1575878 - 699 WP_004177238.1 GNAT family N-acetyltransferase -
ICN80_RS07520 1575979..1577430 + 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
ICN80_RS07525 1577405..1577875 - 471 WP_002892026.1 YlaC family protein -
ICN80_RS07530 1577896..1578036 + 141 WP_004147370.1 hypothetical protein -
ICN80_RS07535 1578008..1578574 - 567 WP_002892030.1 maltose O-acetyltransferase -
ICN80_RS07540 1578733..1578951 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ICN80_RS07545 1578978..1579352 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
ICN80_RS07550 1579838..1582984 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
ICN80_RS07555 1583007..1584200 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T172455 WP_002892050.1 NZ_CP061350:c1578951-1578733 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T172455 NZ_CP079766:c31298-30918 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTGATAGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTCCAGGCCAGAGTTGTGTACGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACAGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGCCACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT172455 WP_002892066.1 NZ_CP061350:c1579352-1578978 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT172455 NZ_CP079766:c31519-31298 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACTCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References