Detailed information of TA system TA172453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 916908..918245
• Replicon: chromosome
• Accession: NZ_CP061350
• Organism: Klebsiella pneumoniae strain ENT1988

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: ICN80_RS04385
• Protein ID: WP_032424556.1
• Coordinates: 916908..917843 (-)
• Length: 312 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: ICN80_RS04390
• Protein ID: WP_023302769.1
• Coordinates: 917850..918245 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICN80_RS04370	913134..914813	+	1680	WP_004212561.1	tyrosine-type recombinase/integrase	-
ICN80_RS04375	915232..916026	+	795	WP_023302766.1	RES domain-containing protein	-
ICN80_RS04380	916211..916900	+	690	WP_023302767.1	hypothetical protein	-
ICN80_RS04385	916908..917843	-	936	WP_032424556.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ICN80_RS04390	917850..918245	-	396	WP_023302769.1	hypothetical protein	Antitoxin
ICN80_RS04395	918500..918766	+	267	WP_023302770.1	hypothetical protein	-
ICN80_RS04400	918772..919236	-	465	WP_022615700.1	GNAT family N-acetyltransferase	-
ICN80_RS04405	919408..921003	-	1596	WP_023302771.1	TraI domain-containing protein	-
ICN80_RS04410	921177..921548	-	372	WP_022615702.1	hypothetical protein	-
ICN80_RS04415	921741..922646	-	906	WP_022615703.1	DUF1738 domain-containing protein	-
ICN80_RS04420	922711..923001	-	291	WP_022615704.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-298)

Antitoxin

• Protein of unknown function DUF6088 (7-109)

Sequences

Toxin

Protein

• Length: 312 a.a.
• Molecular weight: 35389.66 Da
• Isoelectric Point: 5.6165

>T172453 WP_032424556.1 NZ_CP061350:c917843-916908 [Klebsiella pneumoniae]
MLFSDVTDALGIESGAIVEKDHYIVELLHLLKPLTFDTHQLLFAGGTALAKSGIVLNRMSEDVDIKLVPTDTFLSLSRTQ
RKGIRKEIVQTISHAITATDMFSFDDAHPKVTRDEYRYNDIPVRYPQRVAQAPCLRPFIQLELMEANLLEAPEFRDIHTL
VTTLTGKAPVISAFPCATIISTQAEKLVAMLRRTAAVARNIERQDDASLVRHIYDTYCIVQAGNVDMCLLTDFFKQTIEQ
DIQRYGNQYPQFCVSPNDELKMGLDELEHNPLYKTRYQQFVAPMVYGARKVSWDEAYASFRQMALIILDTY

Nucleotide

• Length: 936 bp

>T172453 NZ_CP079762:4961429-4961746 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14800.08 Da
• Isoelectric Point: 11.1078

>AT172453 WP_023302769.1 NZ_CP061350:c918245-917850 [Klebsiella pneumoniae]
MTIKTRIQSRLKRSKRYVFTRDDFKDIAGYDQIGRVLRDLLKEGQLLKVGYGVYTKARRNSITGKVMPAAPRGSSAVIVE
TLERLKVRYRYEGATQTYNSGESTQIPVSPEIKTSPRFKRALSVGNSKLNG

Nucleotide

• Length: 396 bp

>AT172453 NZ_CP079762:4961739-4962026 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA