172442

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2119217..2119746 Replicon chromosome
Accession NZ_CP061349
Organism Staphylococcus aureus strain MSSA01

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IC588_RS10505 Protein ID WP_000621175.1
Coordinates 2119217..2119579 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IC588_RS10510 Protein ID WP_000948331.1
Coordinates 2119576..2119746 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC588_RS10485 2116196..2116966 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
IC588_RS10490 2116941..2117420 - 480 WP_001190829.1 anti-sigma B factor RsbW -
IC588_RS10495 2117422..2117748 - 327 WP_001052491.1 anti-sigma factor antagonist -
IC588_RS10500 2117867..2118868 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IC588_RS10505 2119217..2119579 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IC588_RS10510 2119576..2119746 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IC588_RS10515 2119831..2120979 - 1149 WP_000130547.1 alanine racemase -
IC588_RS10520 2121045..2121404 - 360 WP_000581202.1 holo-ACP synthase -
IC588_RS10525 2121408..2121899 - 492 WP_001205912.1 PH domain-containing protein -
IC588_RS10530 2121886..2123469 - 1584 WP_001294620.1 PH domain-containing protein -
IC588_RS10535 2123462..2123941 - 480 WP_001287079.1 hypothetical protein -
IC588_RS10540 2124150..2124710 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T172442 WP_000621175.1 NZ_CP061349:c2119579-2119217 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T172442 NZ_CP079759:1914657-1914908 [Bacillus sp. LJBS17]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATTAAGGATTACTTCAGCAGCGAAGCACAAACACTAA
TCAATGCAATCTTTGTAGTCACATGTATCATTGCCATATTGTTGTGGATCATCTATTTTGTATTCATTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT172442 WP_000948331.1 NZ_CP061349:c2119746-2119576 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT172442 NZ_CP079759:c1914679-1914579 [Bacillus sp. LJBS17]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References