Detailed information of TA system TA172441

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1962937..1963713
• Replicon: chromosome
• Accession: NZ_CP061349
• Organism: Staphylococcus aureus strain MSSA01

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: IC588_RS09585
• Protein ID: WP_000031108.1
• Coordinates: 1962937..1963089 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: IC588_RS09590
• Protein ID: WP_001251224.1
• Coordinates: 1963114..1963713 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC588_RS09570	1958552..1959373	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
IC588_RS09575	1959834..1961219	-	1386	WP_000116224.1	class II fumarate hydratase	-
IC588_RS09580	1961415..1961810	-	396	WP_000901021.1	hypothetical protein	-
IC588_RS09585	1962937..1963089	-	153	WP_000031108.1	hypothetical protein	Toxin
IC588_RS09590	1963114..1963713	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
IC588_RS09595	1963871..1964341	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
IC588_RS09600	1964346..1965473	-	1128	WP_000379985.1	tRNA epoxyqueuosine(34) reductase QueG	-
IC588_RS09605	1965624..1966346	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
IC588_RS09610	1966339..1967796	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T172441 WP_000031108.1 NZ_CP061349:c1963089-1962937 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T172441 NZ_CP079759:1914462-1914638 [Bacillus sp. LJBS17]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT172441 WP_001251224.1 NZ_CP061349:c1963713-1963114 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT172441 NZ_CP079759:c1914679-1914579 [Bacillus sp. LJBS17]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4