Detailed information of TA system TA172406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 374419..375014
• Replicon: chromosome
• Accession: NZ_CP061339
• Organism: Escherichia coli strain M00057

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: IC755_RS01775
• Protein ID: WP_000239581.1
• Coordinates: 374664..375014 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: IC755_RS01770
• Protein ID: WP_001223213.1
• Coordinates: 374419..374670 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC755_RS01760	370084..373863	+	3780	WP_000060960.1	autotransporter assembly complex protein TamB	-
IC755_RS01765	373866..374207	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
IC755_RS01770	374419..374670	+	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
IC755_RS01775	374664..375014	+	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
IC755_RS01780	375093..375623	-	531	WP_000055075.1	inorganic diphosphatase	-
IC755_RS01785	375933..376889	+	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
IC755_RS01790	377029..378531	+	1503	WP_000205837.1	sugar ABC transporter ATP-binding protein	-
IC755_RS01795	378545..379567	+	1023	WP_001367697.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T172406 WP_000239581.1 NZ_CP061339:374664-375014 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T172406 NZ_CP079749:33937-34230 [Acinetobacter johnsonii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGGGATCAATTTAA
GAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTGAGAGGCGATCTTGCAGGTTGCTATAAAA
TTAAATTATTAAAAGCTGGTGTCAGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATCACAGTCGGG
AAACGAGCTGATAGCATAGTTTATGACGAAGCTAAAAAGCGCATTAAAGACTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT172406 WP_001223213.1 NZ_CP061339:374419-374670 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT172406 NZ_CP079749:33702-33947 [Acinetobacter johnsonii]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCCTATTCCATCCTTAAAGAACAAGGTATTGCACC
TACAGATTTCTTTACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTACCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTGTTAGCTCTTGTCCGTAAGCGCATTAATGACCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7