Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2135222..2135860 Replicon chromosome
Accession NZ_CP061337
Organism Escherichia coli strain M11957

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag IC756_RS10235 Protein ID WP_000813797.1
Coordinates 2135222..2135398 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IC756_RS10240 Protein ID WP_076611057.1
Coordinates 2135444..2135860 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC756_RS10215 2130844..2132055 - 1212 WP_001323162.1 BenE family transporter YdcO -
IC756_RS10220 2132108..2132644 + 537 WP_000429161.1 DNA-binding transcriptional regulator SutR -
IC756_RS10225 2132717..2134678 + 1962 WP_001309488.1 23S rRNA 5-hydroxycytidine C2501 synthase -
IC756_RS10230 2134770..2135000 - 231 WP_000494244.1 YncJ family protein -
IC756_RS10235 2135222..2135398 + 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
IC756_RS10240 2135444..2135860 + 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
IC756_RS10245 2135939..2137345 + 1407 WP_000760613.1 PLP-dependent aminotransferase family protein -
IC756_RS10250 2137590..2138735 + 1146 WP_000047449.1 ABC transporter substrate-binding protein -
IC756_RS10255 2138753..2139766 + 1014 WP_000220413.1 ABC transporter ATP-binding protein -
IC756_RS10260 2139767..2140708 + 942 WP_001251335.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T172387 WP_000813797.1 NZ_CP061337:2135222-2135398 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T172387 NZ_CP079747:210778-210885 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT172387 WP_076611057.1 NZ_CP061337:2135444-2135860 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT172387 NZ_CP079747:c210720-210664 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References