Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1307938..1308521 Replicon chromosome
Accession NZ_CP061318
Organism Polynucleobacter sp. AP-Ainpum-60-G11

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FD971_RS06775 Protein ID WP_215333504.1
Coordinates 1308327..1308521 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FD971_RS06770 Protein ID WP_215333503.1
Coordinates 1307938..1308330 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD971_RS06760 (FD971_06760) 1304776..1306539 + 1764 WP_215333501.1 tetratricopeptide repeat protein -
FD971_RS06765 (FD971_06765) 1306894..1307862 + 969 WP_215333502.1 tripartite tricarboxylate transporter substrate binding protein BugE -
FD971_RS06770 (FD971_06770) 1307938..1308330 - 393 WP_215333503.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FD971_RS06775 (FD971_06775) 1308327..1308521 - 195 WP_215333504.1 type II toxin-antitoxin system HicA family toxin Toxin
FD971_RS06780 (FD971_06780) 1308567..1311056 - 2490 WP_251368600.1 DNA internalization-related competence protein ComEC/Rec2 -
FD971_RS06785 (FD971_06785) 1311061..1311921 - 861 WP_215333505.1 TatD family hydrolase -
FD971_RS06790 (FD971_06790) 1311918..1312625 - 708 WP_251368601.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1300497..1317794 17297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7190.49 Da        Isoelectric Point: 10.6954

>T172344 WP_215333504.1 NZ_CP061318:c1308521-1308327 [Polynucleobacter sp. AP-Ainpum-60-G11]
MHSKKLIERLKVDGWVLSRTRGSHHIFTHTTKSGHICIPHPKKDLGLGLVEKILKQADIEGGLK

Download         Length: 195 bp

>T172344 NZ_CP079735:2656176-2656283 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14317.52 Da        Isoelectric Point: 4.8154

>AT172344 WP_215333503.1 NZ_CP061318:c1308330-1307938 [Polynucleobacter sp. AP-Ainpum-60-G11]
MKYPIAIEPGNAKEIWGVVVPDLAGCFSAGDNSIDEAIENAKEAIELWIEVALDRNQDIPKPSSISELQKKKEFKGWVWA
IVEIDPALLSDEIERINITLPKRVLARLDAKAKKAGENRSAFIAHLALAA

Download         Length: 393 bp

>AT172344 NZ_CP079735:c2656129-2656063 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References