Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 708361..708963 Replicon chromosome
Accession NZ_CP061318
Organism Polynucleobacter sp. AP-Ainpum-60-G11

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FD971_RS03670 Protein ID WP_215334749.1
Coordinates 708673..708963 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag FD971_RS03665 Protein ID WP_215334748.1
Coordinates 708361..708663 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD971_RS03655 (FD971_03655) 703700..706594 + 2895 WP_215334746.1 formate dehydrogenase subunit alpha -
FD971_RS03660 (FD971_03660) 706699..708360 + 1662 WP_215334747.1 L-aspartate oxidase -
FD971_RS03665 (FD971_03665) 708361..708663 - 303 WP_215334748.1 putative addiction module antidote protein Antitoxin
FD971_RS03670 (FD971_03670) 708673..708963 - 291 WP_215334749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FD971_RS03675 (FD971_03675) 709038..709892 - 855 WP_215334750.1 carboxylating nicotinate-nucleotide diphosphorylase -
FD971_RS03680 (FD971_03680) 709936..711063 - 1128 WP_215334751.1 quinolinate synthase NadA -
FD971_RS03685 (FD971_03685) 711113..712498 - 1386 WP_215334752.1 phosphomannomutase/phosphoglucomutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11038.88 Da        Isoelectric Point: 10.2909

>T172343 WP_215334749.1 NZ_CP061318:c708963-708673 [Polynucleobacter sp. AP-Ainpum-60-G11]
MIEIRKTEEFIVWLDNLFDLLARAKMQARIKRLSEGNPGNAESVGEKVFEMKIDFGPGYRVYYTKHGQTLTILLLGGDKK
TQARDIKLAQRLARNL

Download         Length: 291 bp

>T172343 NZ_CP079735:2655641-2655748 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10677.35 Da        Isoelectric Point: 8.0231

>AT172343 WP_215334748.1 NZ_CP061318:c708663-708361 [Polynucleobacter sp. AP-Ainpum-60-G11]
MKRTITTPYDVAEHLRTPKEMAAYLEACIEEADGDAAFIAKALGDIARAKGMTQVAKDSGLTRESLYKSLSGERSPGFDT
ILKVIAALGLSLHAAPAIKK

Download         Length: 303 bp

>AT172343 NZ_CP079735:c2655594-2655528 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References