Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1305204..1305787 Replicon chromosome
Accession NZ_CP061316
Organism Polynucleobacter sp. AP-Jannik-300A-C4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FD975_RS06845 Protein ID WP_215301323.1
Coordinates 1305593..1305787 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FD975_RS06840 Protein ID WP_215301320.1
Coordinates 1305204..1305596 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD975_RS06815 (FD975_06810) 1300960..1301928 + 969 WP_215301311.1 tripartite tricarboxylate transporter substrate binding protein BugE -
FD975_RS06820 (FD975_06815) 1302071..1302352 - 282 WP_215301313.1 hypothetical protein -
FD975_RS06825 (FD975_06820) 1302363..1302896 - 534 WP_215301315.1 hypothetical protein -
FD975_RS06830 (FD975_06825) 1303077..1303427 - 351 WP_215301316.1 hypothetical protein -
FD975_RS06835 (FD975_06830) 1303622..1305148 + 1527 WP_215301318.1 glycosyltransferase -
FD975_RS06840 (FD975_06835) 1305204..1305596 - 393 WP_215301320.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FD975_RS06845 (FD975_06840) 1305593..1305787 - 195 WP_215301323.1 type II toxin-antitoxin system HicA family toxin Toxin
FD975_RS06850 (FD975_06845) 1305841..1308330 - 2490 WP_251371169.1 DNA internalization-related competence protein ComEC/Rec2 -
FD975_RS06855 (FD975_06850) 1308335..1309195 - 861 WP_215301325.1 TatD family hydrolase -
FD975_RS06860 (FD975_06855) 1309192..1309902 - 711 WP_215301327.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1305204..1315059 9855


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7332.72 Da        Isoelectric Point: 10.8795

>T172341 WP_215301323.1 NZ_CP061316:c1305787-1305593 [Polynucleobacter sp. AP-Jannik-300A-C4]
MHSKKLIELLTSDGWVLSRMRGSHHIFIHRTKDGHICIPHPKKDLGLGLVEKILKQADIKRGNK

Download         Length: 195 bp

>T172341 NZ_CP079735:2289772-2291094 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14412.63 Da        Isoelectric Point: 5.2973

>AT172341 WP_215301320.1 NZ_CP061316:c1305596-1305204 [Polynucleobacter sp. AP-Jannik-300A-C4]
MKYPIAIEPGSSKEAWGVVVPDLAGCFSAGDRDIDEAIENAKEAIEIWIELALGHNQEIPKPSSLRELQKRKEFKGWVWA
IVEIDPALLSDEIERINITLPKRVLARLDAKAKKAGENRSAFIAHLALTA

Download         Length: 393 bp

>AT172341 NZ_CP079735:2289506-2289772 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References