Detailed information of TA system TA172339

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 267066..267597
• Replicon: chromosome
• Accession: NZ_CP061316
• Organism: Polynucleobacter sp. AP-Jannik-300A-C4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FD975_RS01445
• Protein ID: WP_215302513.1
• Coordinates: 267066..267356 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FD975_RS01450
• Protein ID: WP_215302514.1
• Coordinates: 267343..267597 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD975_RS01410 (FD975_01410)	262079..263230	-	1152	WP_215302507.1	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	-
FD975_RS01415 (FD975_01415)	263362..263700	+	339	WP_215302508.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
FD975_RS01420 (FD975_01420)	263630..264277	+	648	WP_215302509.1	hypothetical protein	-
FD975_RS01425 (FD975_01425)	264277..264606	+	330	WP_215302510.1	hypothetical protein	-
FD975_RS01430 (FD975_01430)	264619..265197	+	579	WP_251371318.1	GspH/FimT family pseudopilin	-
FD975_RS01435 (FD975_01435)	265247..266365	+	1119	WP_215302511.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
FD975_RS01440 (FD975_01440)	266448..267065	+	618	WP_215302512.1	riboflavin synthase	-
FD975_RS01445 (FD975_01445)	267066..267356	-	291	WP_215302513.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FD975_RS01450 (FD975_01450)	267343..267597	-	255	WP_215302514.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FD975_RS01455 (FD975_01455)	267686..268426	-	741	WP_215302515.1	7-cyano-7-deazaguanine synthase QueC	-
FD975_RS01460 (FD975_01460)	268458..269189	-	732	WP_215302516.1	tol-pal system protein YbgF	-
FD975_RS01465 (FD975_01465)	269189..269689	-	501	WP_215302517.1	peptidoglycan-associated lipoprotein Pal	-
FD975_RS01470 (FD975_01470)	269808..271061	-	1254	WP_251371437.1	Tol-Pal system beta propeller repeat protein TolB	-
FD975_RS01475 (FD975_01475)	271143..272018	-	876	WP_215302519.1	energy transducer TonB	-
FD975_RS01480 (FD975_01480)	272038..272457	-	420	WP_215302520.1	protein TolR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-70)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11218.20 Da
• Isoelectric Point: 10.7148

>T172339 WP_215302513.1 NZ_CP061316:c267356-267066 [Polynucleobacter sp. AP-Jannik-300A-C4]
MKTYSLEFNVLALKEWQKLDNSVRSQFKKQLEKRIQNPRIASAKLHGDLDNFYKIKLAALGYRLVYEVIDHRLIVLIIAV
GKRNQSAVYKEAGKRK

Nucleotide

• Length: 291 bp

>T172339 NZ_CP079735:1957799-1957902 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9242.87 Da
• Isoelectric Point: 9.5955

>AT172339 WP_215302514.1 NZ_CP061316:c267597-267343 [Polynucleobacter sp. AP-Jannik-300A-C4]
MTITQTIHAKTTVSMTDLRRNPSKILEIAGDLPVAVLNHNKPEAYLLSAKAYEALLDLVDDLSLIKVIKARSTGKTVKVK
LEDL

Nucleotide

• Length: 255 bp

>AT172339 NZ_CP079735:c1957940-1957669 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT