Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1344935..1345524 Replicon chromosome
Accession NZ_CP061315
Organism Polynucleobacter sp. AP-Kolm-20A-A1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C2745_RS06705 Protein ID WP_215383596.1
Coordinates 1345141..1345524 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C2745_RS06700 Protein ID WP_215383595.1
Coordinates 1344935..1345138 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2745_RS06690 (C2745_06690) 1341099..1343669 + 2571 WP_215383594.1 cyanophycin synthetase -
C2745_RS06695 (C2745_06695) 1343756..1344718 - 963 WP_215385649.1 class 1 fructose-bisphosphatase -
C2745_RS06700 (C2745_06700) 1344935..1345138 + 204 WP_215383595.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C2745_RS06705 (C2745_06705) 1345141..1345524 + 384 WP_215383596.1 PIN domain-containing protein Toxin
C2745_RS06710 (C2745_06710) 1345521..1348130 - 2610 WP_215383597.1 aminopeptidase N -
C2745_RS06715 (C2745_06715) 1348184..1348759 - 576 WP_215383599.1 TMEM165/GDT1 family protein -
C2745_RS06720 (C2745_06720) 1348853..1349971 - 1119 WP_215383601.1 alanine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14086.33 Da        Isoelectric Point: 7.8281

>T172337 WP_215383596.1 NZ_CP061315:1345141-1345524 [Polynucleobacter sp. AP-Kolm-20A-A1]
MTMVLVDTSVWVAHFRKSNTSFESLLVNDQVLCHPLVLMELACGTPPAPREKFLSNLQKLQQATVATTSETLKLIERHKL
YESGCGAIDVSLLSSTLLSKNASLWTFDKHLETLASRLGISYGNKLH

Download         Length: 384 bp

>T172337 NZ_CP079735:1791105-1791359 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7611.79 Da        Isoelectric Point: 10.4482

>AT172337 WP_215383595.1 NZ_CP061315:1344935-1345138 [Polynucleobacter sp. AP-Kolm-20A-A1]
MRTTVTIDDDLYQRGLDLADPEMDKADLFREAINVFIRVQVAKRLAALGGKSPQMKAVPRRRPRDGQ

Download         Length: 204 bp

>AT172337 NZ_CP079735:1790857-1791108 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References