Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1317712..1318343 Replicon chromosome
Accession NZ_CP061315
Organism Polynucleobacter sp. AP-Kolm-20A-A1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C2745_RS06585 Protein ID WP_215383576.1
Coordinates 1317712..1318110 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C2745_RS06590 Protein ID WP_251368306.1
Coordinates 1318110..1318343 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2745_RS06570 (C2745_06570) 1313626..1314309 - 684 WP_215383573.1 outer membrane lipoprotein carrier protein LolA -
C2745_RS06575 (C2745_06575) 1314316..1316628 - 2313 WP_215383574.1 DNA translocase FtsK -
C2745_RS06580 (C2745_06580) 1316668..1317624 + 957 WP_215383575.1 thioredoxin-disulfide reductase -
C2745_RS06585 (C2745_06585) 1317712..1318110 - 399 WP_215383576.1 type II toxin-antitoxin system VapC family toxin Toxin
C2745_RS06590 (C2745_06590) 1318110..1318343 - 234 WP_251368306.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C2745_RS06595 (C2745_06595) 1318405..1318602 - 198 WP_215383578.1 hypothetical protein -
C2745_RS06600 (C2745_06600) 1318706..1320766 - 2061 WP_215383579.1 sodium-translocating pyrophosphatase -
C2745_RS06605 (C2745_06605) 1320961..1321497 + 537 WP_215383580.1 inorganic diphosphatase -
C2745_RS06610 (C2745_06610) 1321541..1323160 + 1620 WP_215383581.1 NAD+ synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14784.17 Da        Isoelectric Point: 7.4640

>T172336 WP_215383576.1 NZ_CP061315:c1318110-1317712 [Polynucleobacter sp. AP-Kolm-20A-A1]
MLKYLLDTNIVIYVIKQKPLEALKVFNKNANRMAISAITLAELIYGAEKSASVEKNLNVIEDFISHLEVLPYDIAATQHY
GQIKAFLERAGQPIGVNDIHIAAHARSHGLTLVTNNMSEFKRVPNLALENWV

Download         Length: 399 bp

>T172336 NZ_CP079735:1790857-1791108 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8826.92 Da        Isoelectric Point: 5.0959

>AT172336 WP_251368306.1 NZ_CP061315:c1318343-1318110 [Polynucleobacter sp. AP-Kolm-20A-A1]
MAISTVFTNNRTQAVRLPAEMRLPENVRKVNVRSKGRERIIAPIENMWDNFFLGEAGVSEDFMNERGSQEQGDRDSL

Download         Length: 234 bp

>AT172336 NZ_CP079735:1791105-1791359 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References