Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1407121..1407705 Replicon chromosome
Accession NZ_CP061314
Organism Polynucleobacter corsicus strain AP-Melu-1000-A1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C2747_RS07270 Protein ID WP_215330934.1
Coordinates 1407514..1407705 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C2747_RS07265 Protein ID WP_215330933.1
Coordinates 1407121..1407513 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2747_RS07245 (C2747_07225) 1404298..1405269 - 972 WP_215330929.1 dienelactone hydrolase family protein -
C2747_RS07250 (C2747_07230) 1405433..1405873 - 441 WP_215330930.1 tautomerase family protein -
C2747_RS07255 (C2747_07235) 1406033..1406674 - 642 WP_215330931.1 hypothetical protein -
C2747_RS07260 (C2747_07240) 1406733..1407068 - 336 WP_215330932.1 hypothetical protein -
C2747_RS07265 (C2747_07245) 1407121..1407513 - 393 WP_215330933.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C2747_RS07270 (C2747_07250) 1407514..1407705 - 192 WP_215330934.1 type II toxin-antitoxin system HicA family toxin Toxin
C2747_RS07275 (C2747_07255) 1407756..1410245 - 2490 WP_251374728.1 DNA internalization-related competence protein ComEC/Rec2 -
C2747_RS07280 (C2747_07260) 1410250..1411110 - 861 WP_215330935.1 TatD family hydrolase -
C2747_RS07285 (C2747_07265) 1411107..1411802 - 696 WP_215330936.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 6964.26 Da        Isoelectric Point: 10.6230

>T172333 WP_215330934.1 NZ_CP061314:c1407705-1407514 [Polynucleobacter corsicus]
MHSKKLIELLKVDGWVLSRTKGSHHIFTHTTKSGHVCIPHPKKDLGLGLVEKILKQAGLKEGS

Download         Length: 192 bp

>T172333 NZ_CP079735:984468-984803 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14204.42 Da        Isoelectric Point: 4.9844

>AT172333 WP_215330933.1 NZ_CP061314:c1407513-1407121 [Polynucleobacter corsicus]
MKYPIAIEPGNEKNAWGVVVPDLPGCFSAADSGLDEAIDQAKEAIELWIEMALDGGQAIPKPSSLRELQKKKEFKGWAWA
IVEIDPALLSDEIERINITLPKRVLARLDAKAKKAGENRSAFIAHLALTA

Download         Length: 393 bp

>AT172333 NZ_CP079735:984220-984468 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References