Detailed information of TA system TA172326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1340716..1341305
• Replicon: chromosome
• Accession: NZ_CP061306
• Organism: Polynucleobacter sp. JS-JIR-II-b4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ICV90_RS06750
• Protein ID: WP_215357396.1
• Coordinates: 1340922..1341305 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ICV90_RS06745
• Protein ID: WP_215357394.1
• Coordinates: 1340716..1340919 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICV90_RS06735 (ICV90_06745)	1336912..1339482	+	2571	WP_215357384.1	cyanophycin synthetase	-
ICV90_RS06740 (ICV90_06750)	1339548..1340546	-	999	WP_215357393.1	class 1 fructose-bisphosphatase	-
ICV90_RS06745 (ICV90_06755)	1340716..1340919	+	204	WP_215357394.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
ICV90_RS06750 (ICV90_06760)	1340922..1341305	+	384	WP_215357396.1	type II toxin-antitoxin system VapC family toxin	Toxin
ICV90_RS06755 (ICV90_06765)	1341310..1343919	-	2610	WP_215357398.1	aminopeptidase N	-
ICV90_RS06760 (ICV90_06770)	1343965..1344540	-	576	WP_215357400.1	TMEM165/GDT1 family protein	-
ICV90_RS06765 (ICV90_06775)	1344628..1345746	-	1119	WP_215357408.1	alanine dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-129)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14167.53 Da
• Isoelectric Point: 7.2911

>T172326 WP_215357396.1 NZ_CP061306:1340922-1341305 [Polynucleobacter sp. JS-JIR-II-b4]
MTMVLVDTSVWVAHFRKSNASFEALLLNDQILCHPLIQIELACGSPPSPRSKTLGYIKKLRQATIATPYEILEFIEKHQL
QESGCGAIDMSLLTSTLLSENAQLWTLDKSLEKLAIRLGISYGNKLH

Nucleotide

• Length: 384 bp

>T172326 NZ_CP079727:c55573-55157 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCCGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7571.76 Da
• Isoelectric Point: 10.2690

>AT172326 WP_215357394.1 NZ_CP061306:1340716-1340919 [Polynucleobacter sp. JS-JIR-II-b4]
MRTTVTIDDDLYQRGLDLADPDMDKADLFREAINVFIRVQVAKRLVALGGKSPQMKATPRRKPKDGQ

Nucleotide

• Length: 204 bp

>AT172326 NZ_CP079727:c55800-55570 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGAGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA