Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 104453..105039 Replicon chromosome
Accession NZ_CP061306
Organism Polynucleobacter sp. JS-JIR-II-b4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ICV90_RS00615 Protein ID WP_215358863.1
Coordinates 104914..105039 (-) Length 42 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ICV90_RS00610 Protein ID WP_215360270.1
Coordinates 104453..104845 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICV90_RS00585 (ICV90_00585) 100426..101493 - 1068 WP_215358859.1 histidinol-phosphate transaminase -
ICV90_RS00590 (ICV90_00590) 101610..102197 + 588 WP_215321305.1 imidazoleglycerol-phosphate dehydratase HisB -
ICV90_RS00595 (ICV90_00595) 102249..102905 + 657 WP_215358860.1 imidazole glycerol phosphate synthase subunit HisH -
ICV90_RS00600 (ICV90_00600) 102924..103685 + 762 WP_215358861.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
ICV90_RS00605 (ICV90_00605) 103685..104443 + 759 WP_215358862.1 imidazole glycerol phosphate synthase subunit HisF -
ICV90_RS00610 (ICV90_00610) 104453..104845 - 393 WP_215360270.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ICV90_RS00615 (ICV90_00615) 104914..105039 - 126 WP_215358863.1 type II toxin-antitoxin system HicA family toxin Toxin
ICV90_RS00620 (ICV90_00620) 105174..105563 + 390 WP_215358864.1 phosphoribosyl-AMP cyclohydrolase -
ICV90_RS00625 (ICV90_00625) 105650..105910 + 261 WP_215360272.1 type II toxin-antitoxin system VapB family antitoxin -
ICV90_RS00630 (ICV90_00630) 105919..106305 + 387 WP_251367747.1 type II toxin-antitoxin system VapC family toxin -
ICV90_RS00635 (ICV90_00635) 106323..106724 + 402 WP_215358865.1 phosphoribosyl-ATP diphosphatase -
ICV90_RS00640 (ICV90_00640) 106749..107105 + 357 WP_215358866.1 histidine triad nucleotide-binding protein -
ICV90_RS00645 (ICV90_00645) 107122..107343 + 222 WP_215358867.1 Sec-independent protein translocase subunit TatA -
ICV90_RS00650 (ICV90_00650) 107401..107877 + 477 WP_215358868.1 Sec-independent protein translocase protein TatB -
ICV90_RS00655 (ICV90_00655) 107915..108706 + 792 WP_215358869.1 twin-arginine translocase subunit TatC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-39)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 42 a.a.        Molecular weight: 4666.39 Da        Isoelectric Point: 10.6868

>T172323 WP_215358863.1 NZ_CP061306:c105039-104914 [Polynucleobacter sp. JS-JIR-II-b4]
MNSKELIKTLEKDGWVLRGSKGSHHVFNHPRKAGHITVPYP

Download         Length: 126 bp

>T172323 NZ_CP079726:58584-59066 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13963.10 Da        Isoelectric Point: 4.7381

>AT172323 WP_215360270.1 NZ_CP061306:c104845-104453 [Polynucleobacter sp. JS-JIR-II-b4]
MKYPIAIEPGGDKLAWSVIVPDMPGCFSAADSGIDEAIENAKEAIGLWIETALDAGEDIPKPSSITDLQKKKVFKGFIWA
IAEINPSLLSDDIERVNISLPKRVLARLDAKAKSAGENRSAFIAHMAISA

Download         Length: 393 bp

>AT172323 NZ_CP079726:58330-58596 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References