Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 546990..547500 Replicon chromosome
Accession NZ_CP061302
Organism Polynucleobacter sp. MG-Unter2-18

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag C2759_RS02935 Protein ID WP_215356177.1
Coordinates 547237..547500 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag C2759_RS02930 Protein ID WP_215356175.1
Coordinates 546990..547247 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2759_RS02915 (C2759_02910) 543105..543947 + 843 WP_215356618.1 formate dehydrogenase accessory sulfurtransferase FdhD -
C2759_RS02920 (C2759_02915) 543989..544555 + 567 WP_041484826.1 dCTP deaminase -
C2759_RS02925 (C2759_02920) 544604..546871 + 2268 WP_215356173.1 arginine/lysine/ornithine decarboxylase -
C2759_RS02930 (C2759_02925) 546990..547247 + 258 WP_215356175.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C2759_RS02935 (C2759_02930) 547237..547500 + 264 WP_215356177.1 Txe/YoeB family addiction module toxin Toxin
C2759_RS02940 (C2759_02935) 547518..549050 - 1533 WP_215356178.1 TRAP transporter large permease subunit -
C2759_RS02945 (C2759_02940) 549047..549598 - 552 WP_215356180.1 TRAP transporter small permease subunit -
C2759_RS02950 (C2759_02945) 549604..551022 - 1419 WP_215356182.1 argininosuccinate lyase -
C2759_RS02955 (C2759_02950) 551066..552046 + 981 WP_215356184.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10384.89 Da        Isoelectric Point: 8.8777

>T172321 WP_215356177.1 NZ_CP061302:547237-547500 [Polynucleobacter sp. MG-Unter2-18]
MLSRVVWTSAAWSDYVYWQGQDKKTLRRINALIKDVMRNPEDGIGKPEELRESLSGFWSRRIDDVHRLVYAIEKDQLVII
ACRYHYQ

Download         Length: 264 bp

>T172321 NZ_CP079725:c4938884-4937967 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCATCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9667.09 Da        Isoelectric Point: 8.0324

>AT172321 WP_215356175.1 NZ_CP061302:546990-547247 [Polynucleobacter sp. MG-Unter2-18]
MRVINFSDARNQFKQVIDQVVNDCDVAIISRRDADDAVVMSLNTYNSMMETLHLLKSPANVKHLEKSLAQYRKGKTKEKA
LVDAE

Download         Length: 258 bp

>AT172321 NZ_CP079725:c4939648-4938890 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References