Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 962387..962864 Replicon chromosome
Accession NZ_CP061299
Organism Polynucleobacter sp. MWH-CaK5

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag GQ367_RS04735 Protein ID WP_215289455.1
Coordinates 962387..962656 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag GQ367_RS04740 Protein ID WP_215289456.1
Coordinates 962640..962864 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ367_RS04710 (GQ367_04705) 958527..959075 - 549 WP_215289451.1 hypothetical protein -
GQ367_RS04715 (GQ367_04710) 959103..959585 - 483 WP_215289452.1 ribosomal protein S18-alanine N-acetyltransferase -
GQ367_RS04720 (GQ367_04715) 959604..960359 - 756 WP_215289453.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB -
GQ367_RS04725 (GQ367_04720) 960360..961937 - 1578 WP_215289454.1 malate synthase A -
GQ367_RS04730 (GQ367_04725) 962133..962303 + 171 WP_180738109.1 hypothetical protein -
GQ367_RS04735 (GQ367_04730) 962387..962656 - 270 WP_215289455.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQ367_RS04740 (GQ367_04735) 962640..962864 - 225 WP_215289456.1 DUF6290 family protein Antitoxin
GQ367_RS04745 (GQ367_04740) 962997..963458 - 462 WP_215289459.1 VOC family protein -
GQ367_RS04750 (GQ367_04745) 963467..965464 - 1998 WP_215289461.1 acetyl-CoA carboxylase biotin carboxylase subunit -
GQ367_RS04755 (GQ367_04750) 965482..967014 - 1533 WP_215289463.1 acyl-CoA carboxylase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin

Protein of unknown function DUF6290

(3-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10361.28 Da        Isoelectric Point: 10.5155

>T172319 WP_215289455.1 NZ_CP061299:c962656-962387 [Polynucleobacter sp. MWH-CaK5]
MVWQIEFDPAAKKELGKLDPQIAKRILKFLKTRLATQADPRKIGEALKGETLGEFWKYRVGDYRIIASIQDKTVCILVLR
IGNRKEIYR

Download         Length: 270 bp

>T172319 NZ_CP079725:c4687587-4687054 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8521.86 Da        Isoelectric Point: 6.3593

>AT172319 WP_215289456.1 NZ_CP061299:c962864-962640 [Polynucleobacter sp. MWH-CaK5]
MLAIRLPEEIESRLGNLAKKTGRTKTFYAREAILEYIDDLEDLYLAEKRLGDIQKGKTKTIKLNQLERELGLAD

Download         Length: 225 bp

>AT172319 NZ_CP079725:c4687864-4687598 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References