Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1078532..1079139 Replicon chromosome
Accession NZ_CP061298
Organism Polynucleobacter paludilacus strain MWH-Mekk-C3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AOC06_RS05720 Protein ID WP_112204489.1
Coordinates 1078532..1078822 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag AOC06_RS05725 Protein ID WP_112204491.1
Coordinates 1078831..1079139 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOC06_RS05695 (AOC06_05700) 1074436..1074696 + 261 WP_215379357.1 PbsX family transcriptional regulator -
AOC06_RS05700 (AOC06_05705) 1074738..1075064 + 327 WP_255879896.1 type II toxin-antitoxin system PemK/MazF family toxin -
AOC06_RS05705 (AOC06_05710) 1075082..1076467 + 1386 WP_215379360.1 phosphomannomutase/phosphoglucomutase -
AOC06_RS05710 (AOC06_05715) 1076468..1077595 + 1128 WP_215379362.1 quinolinate synthase NadA -
AOC06_RS05715 (AOC06_05720) 1077602..1078456 + 855 WP_215379364.1 carboxylating nicotinate-nucleotide diphosphorylase -
AOC06_RS05720 (AOC06_05725) 1078532..1078822 + 291 WP_112204489.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOC06_RS05725 (AOC06_05730) 1078831..1079139 + 309 WP_112204491.1 putative addiction module antidote protein Antitoxin
AOC06_RS05730 (AOC06_05735) 1079151..1080797 - 1647 WP_215379365.1 L-aspartate oxidase -
AOC06_RS05735 (AOC06_05740) 1080838..1081116 - 279 WP_112204496.1 type II toxin-antitoxin system RelE/ParE family toxin -
AOC06_RS05740 (AOC06_05745) 1081116..1081343 - 228 WP_112204498.1 ParD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11102.00 Da        Isoelectric Point: 10.3340

>T172318 WP_112204489.1 NZ_CP061298:1078532-1078822 [Polynucleobacter paludilacus]
MLEIRKTEEFKAWLDSLHDLMGRAKIQARIKRLAEGNPGNTKSVGSKVFEMKIDFGPGYRIYYTQHENVMYLLLIGGNKR
TQVKDIQIAKYLAKNI

Download         Length: 291 bp

>T172318 NZ_CP079725:4053143-4053361 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10972.78 Da        Isoelectric Point: 9.8628

>AT172318 WP_112204491.1 NZ_CP061298:1078831-1079139 [Polynucleobacter paludilacus]
MKKTIISPYDVVEHLRTPKEMALYLQACIEESNGDAAFIARALGDIARAKGMAQVAKESGLSRESLYKALSGDRIPGFDT
VLKVLAALGLSLHTKPTSKARA

Download         Length: 309 bp

>AT172318 NZ_CP079725:4052742-4053116 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References