Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 638895..639426 Replicon chromosome
Accession NZ_CP061298
Organism Polynucleobacter paludilacus strain MWH-Mekk-C3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AOC06_RS03450 Protein ID WP_215292264.1
Coordinates 638895..639176 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag AOC06_RS03455 Protein ID WP_112313890.1
Coordinates 639163..639426 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOC06_RS03435 (AOC06_03440) 636255..636758 + 504 WP_215343537.1 DUF1993 domain-containing protein -
AOC06_RS03440 (AOC06_03445) 636779..637735 - 957 WP_215337359.1 tripartite tricarboxylate transporter substrate binding protein -
AOC06_RS03445 (AOC06_03450) 637732..638799 - 1068 WP_215344735.1 tartrate dehydrogenase -
AOC06_RS03450 (AOC06_03455) 638895..639176 - 282 WP_215292264.1 type II toxin-antitoxin system YafQ family toxin Toxin
AOC06_RS03455 (AOC06_03460) 639163..639426 - 264 WP_112313890.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AOC06_RS03460 (AOC06_03465) 639541..640026 + 486 WP_215337355.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
AOC06_RS03465 (AOC06_03470) 640023..641312 + 1290 WP_215381250.1 Y-family DNA polymerase -
AOC06_RS08805 641339..641473 + 135 WP_255880031.1 hypothetical protein -
AOC06_RS03470 (AOC06_03475) 641608..642060 + 453 WP_112203748.1 Smr/MutS family protein -
AOC06_RS08810 642215..642346 + 132 WP_255880032.1 hypothetical protein -
AOC06_RS03475 (AOC06_03480) 642387..642677 + 291 WP_215272426.1 BrnT family toxin -
AOC06_RS03480 (AOC06_03485) 642637..642948 + 312 WP_215381251.1 BrnA antitoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-76)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11446.08 Da        Isoelectric Point: 9.2930

>T172317 WP_215292264.1 NZ_CP061298:c639176-638895 [Polynucleobacter paludilacus]
MRTTEYTKKFRKDYKRELKGRYRLTLARDFQETLDYLINDWDLPYRYHDHPLAGDWVDHRDCHIKPDLVLIYRKPDQRIL
QLVRLGSHSELSL

Download         Length: 282 bp

>T172317 NZ_CP079725:c3928106-3927789 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9392.81 Da        Isoelectric Point: 5.0651

>AT172317 WP_112313890.1 NZ_CP061298:c639426-639163 [Polynucleobacter paludilacus]
MTANAVVRARINGDIKEEASAILAAMGLTPSDAFRILMTRIAREKTLPFEPLSPNAETIAAMKEARKGNLKSFTSVNDLM
ADLNADD

Download         Length: 264 bp

>AT172317 NZ_CP079725:c3927796-3927509 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References