Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 284572..285203 Replicon chromosome
Accession NZ_CP061298
Organism Polynucleobacter paludilacus strain MWH-Mekk-C3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AOC06_RS01575 Protein ID WP_215380668.1
Coordinates 284805..285203 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AOC06_RS01570 Protein ID WP_215381688.1
Coordinates 284572..284805 (+) Length 78 a.a.

Genomic Context

AOC06_RS01520AOC06_RS01525AOC06_RS01530AOC06_RS01535AOC06_RS01540AOC06_RS01545AOC06_RS01550AOC06_RS01555AOC06_RS01560AOC06_RS01570AOC06_RS01575AOC06_RS01580AOC06_RS01585AOC06_RS01590AOC06_RS01595AOC06_RS01565
Location: 279582..279884 (303 bp)
Type: Others
Protein ID: WP_215272106.1
Location: 279868..280140 (273 bp)
Type: Others
Protein ID: WP_215345208.1
Location: 280177..281085 (909 bp)
Type: Others
Protein ID: WP_255879991.1
Location: 281109..281732 (624 bp)
Type: Others
Protein ID: WP_215380659.1
Location: 281745..282116 (372 bp)
Type: Others
Protein ID: WP_215352395.1
Location: 282138..282899 (762 bp)
Type: Others
Protein ID: WP_215380662.1
Location: 282932..283150 (219 bp)
Type: Others
Protein ID: WP_255879992.1
Location: 283304..283612 (309 bp)
Type: Others
Protein ID: WP_215380665.1
Location: 283715..284260 (546 bp)
Type: Others
Protein ID: WP_255879995.1
Location: 284572..284805 (234 bp)
Type: Antitoxin
Protein ID: WP_215381688.1
Location: 284805..285203 (399 bp)
Type: Toxin
Protein ID: WP_215380668.1
Location: 285251..286738 (1488 bp)
Type: Others
Protein ID: WP_215273695.1
Location: 286771..287913 (1143 bp)
Type: Others
Protein ID: WP_215380670.1
Location: 287941..288915 (975 bp)
Type: Others
Protein ID: WP_215380672.1
Location: 288924..289979 (1056 bp)
Type: Others
Protein ID: WP_215380673.1
Location: 284287..284433 (147 bp)
Type: Others
Protein ID: WP_215380667.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AOC06_RS01520 (AOC06_01520)279582..279884+303WP_215272106.1BrnT family toxin-
AOC06_RS01525 (AOC06_01525)279868..280140+273WP_215345208.1BrnA antitoxin family protein-
AOC06_RS01530 (AOC06_01530)280177..281085+909WP_255879991.1site-specific tyrosine recombinase XerD-
AOC06_RS01535 (AOC06_01535)281109..281732+624WP_215380659.1glycerol-3-phosphate 1-O-acyltransferase PlsY-
AOC06_RS01540 (AOC06_01540)281745..282116+372WP_215352395.1MAPEG family protein-
AOC06_RS01545 (AOC06_01545)282138..282899+762WP_215380662.1GTP cyclohydrolase I-
AOC06_RS01550 (AOC06_01550)282932..283150+219WP_255879992.1hypothetical protein-
AOC06_RS01555 (AOC06_01555)283304..283612+309WP_215380665.1high-potential iron-sulfur protein-
AOC06_RS01560 (AOC06_01560)283715..284260+546WP_255879995.1HPP family protein-
AOC06_RS01565 (AOC06_01565)284287..284433-147WP_215380667.1hypothetical protein-
AOC06_RS01570 (AOC06_01570)284572..284805+234WP_215381688.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
AOC06_RS01575 (AOC06_01575)284805..285203+399WP_215380668.1type II toxin-antitoxin system VapC family toxinToxin
AOC06_RS01580 (AOC06_01580)285251..286738+1488WP_215273695.1mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase-
AOC06_RS01585 (AOC06_01585)286771..287913+1143WP_215380670.1GDP-mannose 4,6-dehydratase-
AOC06_RS01590 (AOC06_01590)287941..288915+975WP_215380672.1GDP-L-fucose synthase-
AOC06_RS01595 (AOC06_01595)288924..289979+1056WP_215380673.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14767.97 Da        Isoelectric Point: 6.2357

>T172313 WP_215380668.1 NZ_CP061298:284805-285203 [Polynucleobacter paludilacus]
MIKYLLDTNIVIYVLKRRPIEALEAFNKNANRMAISSITLSELIYGAEKSANVDKNLEAVEDFVSHLDVLSYDAKASQQY
GQIKAGLEKRGELIGENDIHIAAHAISQGLILVSNNLKEFKRVPNLALENWV

Download         Length: 399 bp

>T172313 NZ_CP079725:697536-697877 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8838.02 Da        Isoelectric Point: 8.7092

>AT172313 WP_215381688.1 NZ_CP061298:284572-284805 [Polynucleobacter paludilacus]
ITTSTVFTNNRSQAVRLPTEARLPDAVKKVIVRTRGHERIITPIENTWDYFFLSGPLVTDDFMSERGEQKPAVRESF

Download         Length: 234 bp

>AT172313 NZ_CP079725:697198-697515 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References