Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 284572..285203 Replicon chromosome
Accession NZ_CP061298
Organism Polynucleobacter paludilacus strain MWH-Mekk-C3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AOC06_RS01575 Protein ID WP_215380668.1
Coordinates 284805..285203 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AOC06_RS01570 Protein ID WP_215381688.1
Coordinates 284572..284805 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOC06_RS01520 (AOC06_01520) 279582..279884 + 303 WP_215272106.1 BrnT family toxin -
AOC06_RS01525 (AOC06_01525) 279868..280140 + 273 WP_215345208.1 BrnA antitoxin family protein -
AOC06_RS01530 (AOC06_01530) 280177..281085 + 909 WP_255879991.1 site-specific tyrosine recombinase XerD -
AOC06_RS01535 (AOC06_01535) 281109..281732 + 624 WP_215380659.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
AOC06_RS01540 (AOC06_01540) 281745..282116 + 372 WP_215352395.1 MAPEG family protein -
AOC06_RS01545 (AOC06_01545) 282138..282899 + 762 WP_215380662.1 GTP cyclohydrolase I -
AOC06_RS01550 (AOC06_01550) 282932..283150 + 219 WP_255879992.1 hypothetical protein -
AOC06_RS01555 (AOC06_01555) 283304..283612 + 309 WP_215380665.1 high-potential iron-sulfur protein -
AOC06_RS01560 (AOC06_01560) 283715..284260 + 546 WP_255879995.1 HPP family protein -
AOC06_RS01565 (AOC06_01565) 284287..284433 - 147 WP_215380667.1 hypothetical protein -
AOC06_RS01570 (AOC06_01570) 284572..284805 + 234 WP_215381688.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AOC06_RS01575 (AOC06_01575) 284805..285203 + 399 WP_215380668.1 type II toxin-antitoxin system VapC family toxin Toxin
AOC06_RS01580 (AOC06_01580) 285251..286738 + 1488 WP_215273695.1 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase -
AOC06_RS01585 (AOC06_01585) 286771..287913 + 1143 WP_215380670.1 GDP-mannose 4,6-dehydratase -
AOC06_RS01590 (AOC06_01590) 287941..288915 + 975 WP_215380672.1 GDP-L-fucose synthase -
AOC06_RS01595 (AOC06_01595) 288924..289979 + 1056 WP_215380673.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14767.97 Da        Isoelectric Point: 6.2357

>T172313 WP_215380668.1 NZ_CP061298:284805-285203 [Polynucleobacter paludilacus]
MIKYLLDTNIVIYVLKRRPIEALEAFNKNANRMAISSITLSELIYGAEKSANVDKNLEAVEDFVSHLDVLSYDAKASQQY
GQIKAGLEKRGELIGENDIHIAAHAISQGLILVSNNLKEFKRVPNLALENWV

Download         Length: 399 bp

>T172313 NZ_CP079725:697536-697877 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8838.02 Da        Isoelectric Point: 8.7092

>AT172313 WP_215381688.1 NZ_CP061298:284572-284805 [Polynucleobacter paludilacus]
ITTSTVFTNNRSQAVRLPTEARLPDAVKKVIVRTRGHERIITPIENTWDYFFLSGPLVTDDFMSERGEQKPAVRESF

Download         Length: 234 bp

>AT172313 NZ_CP079725:697198-697515 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References