Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 283512..284143 Replicon chromosome
Accession NZ_CP061296
Organism Polynucleobacter sp. MWH-P3-07-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ICU98_RS01580 Protein ID WP_215352398.1
Coordinates 283745..284143 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ICU98_RS01575 Protein ID WP_112237333.1
Coordinates 283512..283745 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICU98_RS01525 (ICU98_01525) 278513..278815 + 303 WP_215284412.1 BrnT family toxin -
ICU98_RS01530 (ICU98_01530) 278799..279071 + 273 WP_215272107.1 BrnA antitoxin family protein -
ICU98_RS01535 (ICU98_01535) 279108..280016 + 909 WP_251365363.1 site-specific tyrosine recombinase XerD -
ICU98_RS01540 (ICU98_01540) 280040..280663 + 624 WP_215352394.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
ICU98_RS01545 (ICU98_01545) 280676..281047 + 372 WP_215352395.1 MAPEG family protein -
ICU98_RS01550 (ICU98_01550) 281069..281860 + 792 WP_215352396.1 GTP cyclohydrolase I -
ICU98_RS01555 (ICU98_01555) 281869..282087 + 219 WP_215352397.1 hypothetical protein -
ICU98_RS01560 (ICU98_01560) 282245..282553 + 309 WP_215332538.1 high-potential iron-sulfur protein -
ICU98_RS01565 (ICU98_01565) 282598..283200 + 603 WP_251365364.1 HPP family protein -
ICU98_RS01570 (ICU98_01570) 283227..283373 - 147 WP_158526005.1 hypothetical protein -
ICU98_RS01575 (ICU98_01575) 283512..283745 + 234 WP_112237333.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ICU98_RS01580 (ICU98_01580) 283745..284143 + 399 WP_215352398.1 type II toxin-antitoxin system VapC family toxin Toxin
ICU98_RS01585 (ICU98_01585) 284191..285678 + 1488 WP_215352399.1 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase -
ICU98_RS01590 (ICU98_01590) 285711..286853 + 1143 WP_215352400.1 GDP-mannose 4,6-dehydratase -
ICU98_RS01595 (ICU98_01595) 286945..287895 + 951 WP_251365400.1 GDP-L-fucose synthase -
ICU98_RS01600 (ICU98_01600) 287919..288950 + 1032 WP_251365365.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14841.99 Da        Isoelectric Point: 6.2357

>T172308 WP_215352398.1 NZ_CP061296:283745-284143 [Polynucleobacter sp. MWH-P3-07-1]
MIKYLLDTNIVIYVLKRRPIEALETFNKNANRIAISSITLSELIYGAEKSANVDKNLEAVEDFVSHLDVFSYDAKASQQY
GQIKAGLEKRGELIGENDIHIAAHAISQGLILVSNNLREFKRVPNLALENWV

Download         Length: 399 bp

>T172308 NZ_CP079718:c4415621-4414320 [Shewanella xiamenensis]
ATGAGTACAGCTAAAACGCTTACGCTAGAGATGCACCTCGGTGATTCAATTATCGGGGAATTATCCTTTGATGCGACGAC
CGACACCTTTGCCGTGCATTACACCAAAGACTGGCAGCAAAGTGGATTTCCACTATCCCCAACGATTCCTTTAGATGGCA
CAGGAACGAGCAATCAAATATCAATGTTTTTGGTCAACTTATTGCCAGAAAACAAAGGATTAGATTATCTGATTGAATCG
CTTGGCGTCTCTAAGGGGAATACCTTTGCCTTGATCCGCGCCATTGGTCTCGATACCGCAGGTGCCATCGCTTTCGTTCC
TAAAGGGGCTTTACTGCCTGAAACACAATTGCGGCCAATTAAGGCTGAAGAAGTTATTCAACGCATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTATCGGTAGCGGGTGTTCAACCTAAATTAAACCTGTTTTATAAC
GGGAAAGAATTTGCCTTTGCCGAAGGTACGCTGTCATCGACCCACATAGTTAAATTCGAAAAATATCATCATTTAGTGAT
CAATGAATTTATAACGATGCGTTTAGCCAAAGTGATTGGAATGAATGTGGCGAATGTCGATATTGTTCATTTTGGCAGTT
ACAAAGCCCTTTGTGTTGAACGCTTTGACAGACGTTATATACCAAGCGAGCAAAGAGTGTTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTAAGCAAAAAATATGAACGTAATTTCGGTACGGGGCGCGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTATTTAGTCTTGCTGAAAAATGCGGTAATCCCGTGGCTGCTAAGCAAGACATGTTGC
AATGGACGCTATTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTACTCATTTTTTATGACGCCAAGCGGA
ATGGAGCCAACGCCTTGGTACGATTTGGTCAACGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCGATGGCTATTGA
TGACGAATTTGAGCCAAATAGCATTTACGCCTATCAATTAGCCGCGTTTATGGATGGCTTGGGTTTACCAAGAAACTTAT
TAATCAGTAACTTAACGAGAATGGCGCGAAGAATACCGCAGGCAATAGCGGAGGTGATTTTAATGCTCCCGCCCCTTGAT
GAAGATGAAGCATCATTTGTGGCGCATTACAAAACCCAGTTACTAGCGAGATGTGAACGTTACCTTGGTTTTGTTGACGA
GGTCAGGGATGTGGAAGTGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8777.97 Da        Isoelectric Point: 8.9366

>AT172308 WP_112237333.1 NZ_CP061296:283512-283745 [Polynucleobacter sp. MWH-P3-07-1]
ITTSTVFTNNRSQAVRLPTEARLPDAVKKVIVRTRGHERIITPIENTWDHFFLSGPLVTDDFMSERGEQKPAVRESL

Download         Length: 234 bp

>AT172308 NZ_CP079718:c4415861-4415625 [Shewanella xiamenensis]
ATGGCATCACCGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGAAGGAAAAGTGCTGCTCTTACCCAAGATGT
GGCGGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAGGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGATATCGTTTCGGTTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References