Detailed information of TA system TA172305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1118751..1120366
• Replicon: chromosome
• Accession: NZ_CP061295
• Organism: Polynucleobacter sp. MWH-S4W17

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: C2755_RS05795
• Protein ID: WP_215319933.1
• Coordinates: 1118751..1120091 (-)
• Length: 447 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: C2755_RS05800
• Protein ID: WP_215319935.1
• Coordinates: 1120094..1120366 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2755_RS05780 (C2755_05780)	1115530..1116990	-	1461	WP_215319929.1	HAMP domain-containing sensor histidine kinase	-
C2755_RS05785 (C2755_05785)	1117037..1117990	+	954	WP_216860706.1	hypothetical protein	-
C2755_RS05790 (C2755_05790)	1118097..1118678	+	582	WP_215319931.1	hypothetical protein	-
C2755_RS05795 (C2755_05795)	1118751..1120091	-	1341	WP_215319933.1	type II toxin-antitoxin system HipA family toxin	Toxin
C2755_RS05800 (C2755_05800)	1120094..1120366	-	273	WP_215319935.1	helix-turn-helix transcriptional regulator	Antitoxin
C2755_RS05805 (C2755_05805)	1120498..1121265	-	768	WP_215319937.1	metallophosphoesterase	-
C2755_RS05810 (C2755_05810)	1121437..1122051	+	615	WP_215319939.1	3'-5' exonuclease	-
C2755_RS05820 (C2755_05820)	1122384..1122641	+	258	WP_071465897.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
C2755_RS05825 (C2755_05825)	1122650..1123069	+	420	WP_071465898.1	type II toxin-antitoxin system VapC family toxin	-
C2755_RS05830 (C2755_05830)	1123066..1124199	-	1134	WP_215319941.1	NAD(P)/FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-67)

Sequences

Toxin

Protein

• Length: 447 a.a.
• Molecular weight: 49541.74 Da
• Isoelectric Point: 6.8238

>T172305 WP_215319933.1 NZ_CP061295:c1120091-1118751 [Polynucleobacter sp. MWH-S4W17]
MAARTKSRGLTIWMNGVQVGTWQITRQLESFSYSNEWIMRAEARPLSLSLPFLPGNAAHQGDPVNYYFDNLLPDSDVIRR
RLASRYQVKSLGAFDLLSQLGRDCVGAIQLLPDGELPAEIYQIQGRALSNEEIADHLRRVSSDSVFRQAEQSNDLRLSIA
GAQEKTALLKCDGRWLLPQGSTPTTHILKLPLGLVGHMRADMRTSVENEWLCSKIMAAYGIPTASCEINSFEDQKVLIIE
RFDRRLAADGQWIMRLPQEDFCQAMGISPMSKYQADGGPSITSAMKLLLGSVNAEQDRIHFFKTQIIFWILAATDGHGKN
FSIAHLPGSQYQATPIYDVLSAHPVIGFGANQMAPQKAKLAMAVRGSSNYYLLDKIHYRHWLAQAQQAGLGADVAQQLIG
EVIEMTGFVINQVRSSITGPFPMDVAESIFMGMEEKVQMLASQFST

Nucleotide

• Length: 1341 bp

>T172305 NZ_CP079717:c29953-29651 [Shewanella xiamenensis]
ATGCACGTAATATCAAGAAAGCCTTTTGCTGATGCAATTAAGAAGTTTCCAAACGATGCCTCAGCGATTGAAAGCACATA
CAACGTGCTAAAACGTGGTGACTTTAAAACCCCACAAGAGCTTAGGGCGGTTTTTGGTTCATTGGACAATTTTAAGTACA
AGGATAAGTGGTGGATTATCGACATCGGCGGCAATAACTTAAGAATGCTGGCGTTTATCGAGTTCGTACACAATCGGATT
TATGTAAAGCATATCGTTTCCCACAGTGAGTACGATGCGCTTTGTAAGAAGTATAGAAAATAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10472.34 Da
• Isoelectric Point: 10.5293

>AT172305 WP_215319935.1 NZ_CP061295:c1120366-1120094 [Polynucleobacter sp. MWH-S4W17]
MIYQIQTLETLKLFIRAFRKQKGVTQADMAQKLGISQQAYARFEGNPQLATLERLFLVLRILDVKISLEQIIKNSKEAKT
NMKSESKEIW

Nucleotide

• Length: 273 bp

>AT172305 NZ_CP079717:c29641-29222 [Shewanella xiamenensis]
ATGTTAGCTGTAGCCGAATTAACAAAACTGGCGGGTAACATTATGTCGAATGTGCCTTTGCTGGCTGGCATTAGCAACGC
AGCAGAACATCAGCAAGCACTTGAACTGATGGAAGAACTGTTAGATGACTATGACGCGAATCTCGTGGTTATTGAAGCCC
TGAGCAACGTTATAGCGCGTTATGAGGATGAATCACTTCGGTTCGATATGTTCAACAGTAGACAGGCTGAACTTGATCCA
GCAGTTGCCACGTTAAAAGTGCTGATGGATCAGAACGGACTGAATACCACAGACTTTGAAGCTGAAATCGGCAAAAAAAG
TATGGTGTCGCAGGTATTGGCTGGAAAAAAGAACCTGACCAAAGAACACATTTCTAAGCTGGCTCAGCGCTTCGGCGTAA
ATCCAGCGGTATTTTTTTAA