Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 105626..106281 | Replicon | chromosome |
| Accession | NZ_CP061295 | ||
| Organism | Polynucleobacter sp. MWH-S4W17 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | C2755_RS00625 | Protein ID | WP_251368491.1 |
| Coordinates | 105886..106281 (+) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | C2755_RS00620 | Protein ID | WP_215322236.1 |
| Coordinates | 105626..105886 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C2755_RS00585 (C2755_00585) | 101586..102173 | + | 588 | WP_215321305.1 | imidazoleglycerol-phosphate dehydratase HisB | - |
| C2755_RS00590 (C2755_00590) | 102225..102881 | + | 657 | WP_215321306.1 | imidazole glycerol phosphate synthase subunit HisH | - |
| C2755_RS00595 (C2755_00595) | 102900..103661 | + | 762 | WP_215321307.1 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase | - |
| C2755_RS00600 (C2755_00600) | 103661..104419 | + | 759 | WP_215321308.1 | imidazole glycerol phosphate synthase subunit HisF | - |
| C2755_RS00605 (C2755_00605) | 104429..104821 | - | 393 | WP_215321309.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| C2755_RS00610 (C2755_00610) | 104833..105015 | - | 183 | WP_215321310.1 | type II toxin-antitoxin system HicA family toxin | - |
| C2755_RS00615 (C2755_00615) | 105150..105539 | + | 390 | WP_215321311.1 | phosphoribosyl-AMP cyclohydrolase | - |
| C2755_RS00620 (C2755_00620) | 105626..105886 | + | 261 | WP_215322236.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| C2755_RS00625 (C2755_00625) | 105886..106281 | + | 396 | WP_251368491.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| C2755_RS00630 (C2755_00630) | 106298..106699 | + | 402 | WP_215321312.1 | phosphoribosyl-ATP diphosphatase | - |
| C2755_RS00635 (C2755_00635) | 106724..107080 | + | 357 | WP_215321313.1 | histidine triad nucleotide-binding protein | - |
| C2755_RS00640 (C2755_00640) | 107097..107318 | + | 222 | WP_215321314.1 | Sec-independent protein translocase subunit TatA | - |
| C2755_RS00645 (C2755_00645) | 107376..107852 | + | 477 | WP_072582109.1 | Sec-independent protein translocase protein TatB | - |
| C2755_RS00650 (C2755_00650) | 107892..108683 | + | 792 | WP_215321315.1 | twin-arginine translocase subunit TatC | - |
| C2755_RS00655 (C2755_00655) | 108659..110119 | - | 1461 | WP_215321316.1 | sel1 repeat family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14616.05 Da Isoelectric Point: 8.9351
>T172303 WP_251368491.1 NZ_CP061295:105886-106281 [Polynucleobacter sp. MWH-S4W17]
MRYMLDTNTVSSLIKKNPVVSRKIASVPMERLCLSVISEGEILYGLAKKPNARNLHLVVQEFLKRVDVLVWDTDVAEHYG
VLRAQLEGSGNVLGSLDMQIAAHASQLGAILVTNDQAFKRIKQLKVEDWTV
MRYMLDTNTVSSLIKKNPVVSRKIASVPMERLCLSVISEGEILYGLAKKPNARNLHLVVQEFLKRVDVLVWDTDVAEHYG
VLRAQLEGSGNVLGSLDMQIAAHASQLGAILVTNDQAFKRIKQLKVEDWTV
Download Length: 396 bp
>T172303 NZ_CP079716:c5649424-5649242 [Pseudomonas amygdali]
ATGAAATGCAACGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCGGCCAAGGGTAGTCATTTCAAGGT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGACCATGGCAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA
ATGAAATGCAACGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCGGCCAAGGGTAGTCATTTCAAGGT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGACCATGGCAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9775.91 Da Isoelectric Point: 4.4299
>AT172303 WP_215322236.1 NZ_CP061295:105626-105886 [Polynucleobacter sp. MWH-S4W17]
MGLTAKIFMNGRSQAIRLPAAFRFEEKEVFIRRDPSTGDLILSRRPENWDSFFVALASADVPLDFLSPEDRNQDSQDRDP
FAGVND
MGLTAKIFMNGRSQAIRLPAAFRFEEKEVFIRRDPSTGDLILSRRPENWDSFFVALASADVPLDFLSPEDRNQDSQDRDP
FAGVND
Download Length: 261 bp
>AT172303 NZ_CP079716:c5649210-5648785 [Pseudomonas amygdali]
ATGTATCAATATCCATTGGATCTGCATCGGGAGCCGACAGGCGTTTGGCTTTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTGCCTGAAGCATTGAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGATCAAC
GTCGCAAGATTCCCCAGGCCTCAGTCGTACCCGGCCATGAACTGTTGATGCGTTTGCCTGCGCTGACTGTTGCCAAAATC
ATGCTATGGAACAGCTTGTTGGAAGAGGGCGTTAGCCGTGCTGAGCTGGCGCGTCGCCTGGGTTGTACGCGGCAAGTGGT
GGATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGCCGGCGTATTA
CGTTGAGCATTGAGCGGACCGCTTGA
ATGTATCAATATCCATTGGATCTGCATCGGGAGCCGACAGGCGTTTGGCTTTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTGCCTGAAGCATTGAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGATCAAC
GTCGCAAGATTCCCCAGGCCTCAGTCGTACCCGGCCATGAACTGTTGATGCGTTTGCCTGCGCTGACTGTTGCCAAAATC
ATGCTATGGAACAGCTTGTTGGAAGAGGGCGTTAGCCGTGCTGAGCTGGCGCGTCGCCTGGGTTGTACGCGGCAAGTGGT
GGATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGCCGGCGTATTA
CGTTGAGCATTGAGCGGACCGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|