Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 105626..106281 Replicon chromosome
Accession NZ_CP061295
Organism Polynucleobacter sp. MWH-S4W17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C2755_RS00625 Protein ID WP_251368491.1
Coordinates 105886..106281 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C2755_RS00620 Protein ID WP_215322236.1
Coordinates 105626..105886 (+) Length 87 a.a.

Genomic Context

C2755_RS00585C2755_RS00590C2755_RS00595C2755_RS00600C2755_RS00615C2755_RS00620C2755_RS00625C2755_RS00630C2755_RS00635C2755_RS00640C2755_RS00645C2755_RS00650C2755_RS00605C2755_RS00610C2755_RS00655
Location: 101586..102173 (588 bp)
Type: Others
Protein ID: WP_215321305.1
Location: 102225..102881 (657 bp)
Type: Others
Protein ID: WP_215321306.1
Location: 102900..103661 (762 bp)
Type: Others
Protein ID: WP_215321307.1
Location: 103661..104419 (759 bp)
Type: Others
Protein ID: WP_215321308.1
Location: 105150..105539 (390 bp)
Type: Others
Protein ID: WP_215321311.1
Location: 105626..105886 (261 bp)
Type: Antitoxin
Protein ID: WP_215322236.1
Location: 105886..106281 (396 bp)
Type: Toxin
Protein ID: WP_251368491.1
Location: 106298..106699 (402 bp)
Type: Others
Protein ID: WP_215321312.1
Location: 106724..107080 (357 bp)
Type: Others
Protein ID: WP_215321313.1
Location: 107097..107318 (222 bp)
Type: Others
Protein ID: WP_215321314.1
Location: 107376..107852 (477 bp)
Type: Others
Protein ID: WP_072582109.1
Location: 107892..108683 (792 bp)
Type: Others
Protein ID: WP_215321315.1
Location: 104429..104821 (393 bp)
Type: Others
Protein ID: WP_215321309.1
Location: 104833..105015 (183 bp)
Type: Others
Protein ID: WP_215321310.1
Location: 108659..110119 (1461 bp)
Type: Others
Protein ID: WP_215321316.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C2755_RS00585 (C2755_00585)101586..102173+588WP_215321305.1imidazoleglycerol-phosphate dehydratase HisB-
C2755_RS00590 (C2755_00590)102225..102881+657WP_215321306.1imidazole glycerol phosphate synthase subunit HisH-
C2755_RS00595 (C2755_00595)102900..103661+762WP_215321307.11-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase-
C2755_RS00600 (C2755_00600)103661..104419+759WP_215321308.1imidazole glycerol phosphate synthase subunit HisF-
C2755_RS00605 (C2755_00605)104429..104821-393WP_215321309.1type II toxin-antitoxin system HicB family antitoxin-
C2755_RS00610 (C2755_00610)104833..105015-183WP_215321310.1type II toxin-antitoxin system HicA family toxin-
C2755_RS00615 (C2755_00615)105150..105539+390WP_215321311.1phosphoribosyl-AMP cyclohydrolase-
C2755_RS00620 (C2755_00620)105626..105886+261WP_215322236.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
C2755_RS00625 (C2755_00625)105886..106281+396WP_251368491.1type II toxin-antitoxin system VapC family toxinToxin
C2755_RS00630 (C2755_00630)106298..106699+402WP_215321312.1phosphoribosyl-ATP diphosphatase-
C2755_RS00635 (C2755_00635)106724..107080+357WP_215321313.1histidine triad nucleotide-binding protein-
C2755_RS00640 (C2755_00640)107097..107318+222WP_215321314.1Sec-independent protein translocase subunit TatA-
C2755_RS00645 (C2755_00645)107376..107852+477WP_072582109.1Sec-independent protein translocase protein TatB-
C2755_RS00650 (C2755_00650)107892..108683+792WP_215321315.1twin-arginine translocase subunit TatC-
C2755_RS00655 (C2755_00655)108659..110119-1461WP_215321316.1sel1 repeat family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14616.05 Da        Isoelectric Point: 8.9351

>T172303 WP_251368491.1 NZ_CP061295:105886-106281 [Polynucleobacter sp. MWH-S4W17]
MRYMLDTNTVSSLIKKNPVVSRKIASVPMERLCLSVISEGEILYGLAKKPNARNLHLVVQEFLKRVDVLVWDTDVAEHYG
VLRAQLEGSGNVLGSLDMQIAAHASQLGAILVTNDQAFKRIKQLKVEDWTV

Download         Length: 396 bp

>T172303 NZ_CP079716:c5649424-5649242 [Pseudomonas amygdali]
ATGAAATGCAACGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCGGCCAAGGGTAGTCATTTCAAGGT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGACCATGGCAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9775.91 Da        Isoelectric Point: 4.4299

>AT172303 WP_215322236.1 NZ_CP061295:105626-105886 [Polynucleobacter sp. MWH-S4W17]
MGLTAKIFMNGRSQAIRLPAAFRFEEKEVFIRRDPSTGDLILSRRPENWDSFFVALASADVPLDFLSPEDRNQDSQDRDP
FAGVND

Download         Length: 261 bp

>AT172303 NZ_CP079716:c5649210-5648785 [Pseudomonas amygdali]
ATGTATCAATATCCATTGGATCTGCATCGGGAGCCGACAGGCGTTTGGCTTTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTGCCTGAAGCATTGAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGATCAAC
GTCGCAAGATTCCCCAGGCCTCAGTCGTACCCGGCCATGAACTGTTGATGCGTTTGCCTGCGCTGACTGTTGCCAAAATC
ATGCTATGGAACAGCTTGTTGGAAGAGGGCGTTAGCCGTGCTGAGCTGGCGCGTCGCCTGGGTTGTACGCGGCAAGTGGT
GGATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGCCGGCGTATTA
CGTTGAGCATTGAGCGGACCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References