Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-ChpS
Location 1191094..1191674 Replicon chromosome
Accession NZ_CP061292
Organism Polynucleobacter sp. MWH-UH24A

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag ICV32_RS06280 Protein ID WP_215369089.1
Coordinates 1191094..1191420 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag ICV32_RS06285 Protein ID WP_215369103.1
Coordinates 1191420..1191674 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICV32_RS06255 (ICV32_06250) 1186526..1187392 - 867 WP_215369055.1 dihydropteroate synthase -
ICV32_RS06260 (ICV32_06255) 1187395..1189278 - 1884 WP_215369083.1 ATP-dependent zinc metalloprotease FtsH -
ICV32_RS06265 (ICV32_06260) 1189441..1190106 - 666 WP_215372617.1 RlmE family RNA methyltransferase -
ICV32_RS06270 (ICV32_06265) 1190162..1190617 + 456 WP_215369085.1 YhbY family RNA-binding protein -
ICV32_RS06275 (ICV32_06270) 1190585..1191085 - 501 WP_215369087.1 DUF4149 domain-containing protein -
ICV32_RS06280 (ICV32_06275) 1191094..1191420 - 327 WP_215369089.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ICV32_RS06285 (ICV32_06280) 1191420..1191674 - 255 WP_215369103.1 antitoxin Antitoxin
ICV32_RS06290 (ICV32_06285) 1191739..1192221 - 483 WP_215369105.1 transcription elongation factor GreA -
ICV32_RS06295 (ICV32_06290) 1192260..1195508 - 3249 WP_215369110.1 carbamoyl-phosphate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin

Antitoxin PemI-like

(1-84)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11514.49 Da        Isoelectric Point: 10.3155

>T172295 WP_215369089.1 NZ_CP061292:c1191420-1191094 [Polynucleobacter sp. MWH-UH24A]
MKRGDIYLVSLDPTAGHEQKGYRPVLVVSPAPFNQLTKTPIVVPISTGGQFARVAGFAVELVGTKTTGIVRCDQPRTLDL
VARKAKRVETVSAAVIDDVLAKLATLVT

Download         Length: 327 bp

>T172295 NZ_CP079715:c2609845-2609594 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9088.63 Da        Isoelectric Point: 5.7390

>AT172295 WP_215369103.1 NZ_CP061292:c1191674-1191420 [Polynucleobacter sp. MWH-UH24A]
MHTNLRKVGGSVMLAVSPVFLKELQIACGSTVDVALVEGQLVVRPITKPQYALADLLAQCDPKAKMPSEDRQWLDSSPVG
NEIL

Download         Length: 255 bp

>AT172295 NZ_CP079715:c2609604-2609422 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References