Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 365697..366282 Replicon chromosome
Accession NZ_CP061292
Organism Polynucleobacter sp. MWH-UH24A

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ICV32_RS01940 Protein ID WP_215371482.1
Coordinates 365697..365888 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ICV32_RS01945 Protein ID WP_215371483.1
Coordinates 365890..366282 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICV32_RS01915 (ICV32_01910) 361200..362582 - 1383 WP_215371474.1 N-acetylmuramoyl-L-alanine amidase -
ICV32_RS01920 (ICV32_01915) 362591..363136 - 546 WP_215371476.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
ICV32_RS01925 (ICV32_01920) 363183..364391 + 1209 WP_215371478.1 tRNA epoxyqueuosine(34) reductase QueG -
ICV32_RS01930 (ICV32_01925) 364409..365272 + 864 WP_251371898.1 AzlC family ABC transporter permease -
ICV32_RS01935 (ICV32_01930) 365269..365652 + 384 WP_215371480.1 AzlD domain-containing protein -
ICV32_RS01940 (ICV32_01935) 365697..365888 + 192 WP_215371482.1 type II toxin-antitoxin system HicA family toxin Toxin
ICV32_RS01945 (ICV32_01940) 365890..366282 + 393 WP_215371483.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ICV32_RS01950 (ICV32_01945) 366307..369375 - 3069 WP_215371485.1 FAD-binding and (Fe-S)-binding domain-containing protein -
ICV32_RS01955 (ICV32_01950) 369498..369914 + 417 WP_215371487.1 heme-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 6932.27 Da        Isoelectric Point: 11.5191

>T172293 WP_215371482.1 NZ_CP061292:365697-365888 [Polynucleobacter sp. MWH-UH24A]
MSSKQLIQLLLRDGWRLRSSKGSHHVFVHATKLGHICVPHPKKDLGIGLVQKLLKQAGINKGG

Download         Length: 192 bp

>T172293 NZ_CP079715:c2471223-2471071 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14255.69 Da        Isoelectric Point: 5.2968

>AT172293 WP_215371483.1 NZ_CP061292:365890-366282 [Polynucleobacter sp. MWH-UH24A]
MKYPIAIEIGSLKKSWGVVVPDLPGCFSAADSGIDEAIENAKEAIELWIEVALEKGMEVPKPSLITDLQKKKEFKGWIWA
VAEIDPALLSDEIERINITLPKRVLSRLDAKAKKAGETRSGFIAHLALCA

Download         Length: 393 bp

>AT172293 NZ_CP079715:c2471847-2471248 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References