Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 278531..279130 Replicon chromosome
Accession NZ_CP061291
Organism Polynucleobacter sp. TSB-Sco08W16

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FD961_RS01480 Protein ID WP_215393806.1
Coordinates 278531..278827 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FD961_RS01485 Protein ID WP_215393807.1
Coordinates 278828..279130 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD961_RS01455 (FD961_01455) 274705..275523 - 819 WP_215393802.1 energy transducer TonB -
FD961_RS01460 (FD961_01460) 275562..275981 - 420 WP_215393803.1 protein TolR -
FD961_RS01465 (FD961_01465) 275988..276644 - 657 WP_215393804.1 protein TolQ -
FD961_RS01470 (FD961_01470) 276721..277965 + 1245 WP_215393805.1 serine hydroxymethyltransferase -
FD961_RS01475 (FD961_01475) 277989..278435 + 447 WP_011902126.1 transcriptional regulator NrdR -
FD961_RS01480 (FD961_01480) 278531..278827 + 297 WP_215393806.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FD961_RS01485 (FD961_01485) 278828..279130 + 303 WP_215393807.1 putative addiction module antidote protein Antitoxin
FD961_RS01490 (FD961_01490) 279138..280103 - 966 WP_215393808.1 GDP-mannose 4,6-dehydratase -
FD961_RS01495 (FD961_01495) 280105..280770 - 666 WP_215393809.1 adenylate kinase -
FD961_RS01500 (FD961_01500) 280875..281636 - 762 WP_215393810.1 3-deoxy-manno-octulosonate cytidylyltransferase -
FD961_RS01505 (FD961_01505) 281647..281826 - 180 WP_215393811.1 Trm112 family protein -
FD961_RS01510 (FD961_01510) 281906..282991 - 1086 WP_215393812.1 tetraacyldisaccharide 4'-kinase -
FD961_RS01515 (FD961_01515) 283008..283454 - 447 WP_215393813.1 biopolymer transporter ExbD -
FD961_RS01520 (FD961_01520) 283451..284086 - 636 WP_215393814.1 MotA/TolQ/ExbB proton channel family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(12-98)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11110.94 Da        Isoelectric Point: 10.1772

>T172291 WP_215393806.1 NZ_CP061291:278531-278827 [Polynucleobacter sp. TSB-Sco08W16]
MYEINKTDEFDAWFSGIRDPITRGRLPSRLRKVSLGSLGDIAPVGAGVWEMREHFGAGWRMYYVQHRKTIILMLGGGCKS
AQATDIKRVKKLLLSLED

Download         Length: 297 bp

>T172291 NZ_CP079715:1409916-1410167 [Staphylococcus aureus]
ATGGATAACCGTGAACAAATAGAACAATCAGTGATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGATAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10981.95 Da        Isoelectric Point: 10.3649

>AT172291 WP_215393807.1 NZ_CP061291:278828-279130 [Polynucleobacter sp. TSB-Sco08W16]
MKISKKIKNKNFSKFDVVDYLKTEKDIAGYLSAVLEDGDPALFVAAIGDIAKAKGMTEIAKKSGVTRESLYRALKIEARP
RFETVAKVVHALGMKLSVHA

Download         Length: 303 bp

>AT172291 NZ_CP079715:1410157-1410330 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References