Detailed information of TA system TA172289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 502443..503026
• Replicon: chromosome
• Accession: NZ_CP061289
• Organism: Polynucleobacter sp. UB-Siik-W21

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C2756_RS02670
• Protein ID: WP_215296503.1
• Coordinates: 502443..502637 (+)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C2756_RS02675
• Protein ID: WP_215296504.1
• Coordinates: 502634..503026 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2756_RS02655 (C2756_02655)	498358..499053	+	696	WP_215319813.1	ABC transporter ATP-binding protein	-
C2756_RS02660 (C2756_02660)	499074..499910	+	837	WP_215320780.1	TatD family hydrolase	-
C2756_RS02665 (C2756_02665)	499975..502395	+	2421	WP_215319815.1	DNA internalization-related competence protein ComEC/Rec2	-
C2756_RS02670 (C2756_02670)	502443..502637	+	195	WP_215296503.1	type II toxin-antitoxin system HicA family toxin	Toxin
C2756_RS02675 (C2756_02675)	502634..503026	+	393	WP_215296504.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C2756_RS02685 (C2756_02685)	503417..505258	+	1842	WP_215320782.1	potassium transporter Kup	-
C2756_RS02690 (C2756_02690)	505255..505764	+	510	WP_215296508.1	hypothetical protein	-
C2756_RS02695 (C2756_02695)	505800..507164	+	1365	WP_215319817.1	DNA repair protein RadA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	493156..520000	26844

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7270.61 Da
• Isoelectric Point: 10.9310

>T172289 WP_215296503.1 NZ_CP061289:502443-502637 [Polynucleobacter sp. UB-Siik-W21]
MHSKKVIEKLVRDGWHLRGIRGSHHVYIHPLKQGHIVVTHPRKDMPTGLLKAIFKQAGLMGEGE

Nucleotide

• Length: 195 bp

>T172289 NZ_CP079715:c1361764-1361576 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14298.53 Da
• Isoelectric Point: 4.6948

>AT172289 WP_215296504.1 NZ_CP061289:502634-503026 [Polynucleobacter sp. UB-Siik-W21]
MKYPVAIEPGSKSEAWGVIVPDLPGCFSAADSGIDEAIEKVKEAIELWIEVALDEGQEIPKPSSLRELQKRKEFKGYVWA
IVEIDPALLSDDIERINITLPKRVLARLDAKAKSAGENRSAFIAHLALMA

Nucleotide

• Length: 393 bp

>AT172289 NZ_CP079715:c1362053-1361793 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA