Detailed information of TA system TA172284

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 900190..901733
• Replicon: chromosome
• Accession: NZ_CP061287
• Organism: Polynucleobacter sp. MWH-Aus1W21

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: ICW03_RS04685
• Protein ID: WP_215349591.1
• Coordinates: 900441..901733 (+)
• Length: 431 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: ICW03_RS04680
• Protein ID: WP_215349589.1
• Coordinates: 900190..900441 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICW03_RS04665 (ICW03_04665)	895688..896650	+	963	WP_215349580.1	tripartite tricarboxylate transporter substrate binding protein	-
ICW03_RS04670 (ICW03_04670)	896740..898680	+	1941	WP_215349583.1	hypothetical protein	-
ICW03_RS04675 (ICW03_04675)	898661..899884	+	1224	WP_215349586.1	hypothetical protein	-
ICW03_RS04680 (ICW03_04680)	900190..900441	+	252	WP_215349589.1	type II toxin-antitoxin system Y4mF family antitoxin	Antitoxin
ICW03_RS04685 (ICW03_04685)	900441..901733	+	1293	WP_215349591.1	type II toxin-antitoxin system HipA family toxin	Toxin
ICW03_RS04690 (ICW03_04690)	902055..903101	+	1047	WP_215349593.1	phage major capsid protein	-
ICW03_RS04695 (ICW03_04695)	903158..903490	+	333	WP_215349594.1	hypothetical protein	-
ICW03_RS04700 (ICW03_04700)	903639..904175	+	537	WP_215349596.1	hypothetical protein	-
ICW03_RS04705 (ICW03_04705)	904172..904519	+	348	WP_215349598.1	M15 family metallopeptidase	-
ICW03_RS04710 (ICW03_04710)	904572..905201	+	630	WP_215349600.1	hypothetical protein	-
ICW03_RS04715 (ICW03_04715)	905217..906506	-	1290	WP_215349602.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (148-386)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-63)

Sequences

Toxin

Protein

• Length: 431 a.a.
• Molecular weight: 47040.11 Da
• Isoelectric Point: 5.5015

>T172284 WP_215349591.1 NZ_CP061287:900441-901733 [Polynucleobacter sp. MWH-Aus1W21]
MVRELNVWFFGECVGVLTQDEGYLSFQYLPEWLKSKNAKPLSQSLPLRAEPFGDKIAKPFFAGLLPEGDKRAAVANILKV
SSKNDFALLDGIGGECAGALILLEPGQTPPAEAHASDSIEWLEEDQLLAVLEKLPKRPLLAGESGLRLSLAGAQEKLPVV
AREVFGKDGLSHFEIGLPKNNIPSSYILKPEISGVDGSVYNEAFCLALAGQLKLDAATAKIGKIKDKTYLLVERYDRILD
GNGQLTRLHQEDFCQALGIAPELKYQNEGGPTIADGFALVRKVTTPSAPNLLRLLDHIIFNCLVGNNDAHAKNFSLLYSQ
SGIQLAPLYDVLSTAVYPDLSDSMAMKIGSKYRFDELHARHWVQMAEAAQLGAPQLKRRVLEIAGELPNLAKELQVQFEA
KGWGHPILAQIVSLIEERCATTANRFSLAE

Nucleotide

• Length: 1293 bp

>T172284 NZ_CP079713:3889755-3890087 [Salmonella enterica subsp. arizonae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCGCTGGATCCGATTGCCGGTCACGAGCAAAGCGGAAAACGTCCGGTACTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTGCCCGTTGTCGTTCCCGTCACCAGCGGCGGAAACTTCGCCCGCA
CAGCCGGTTTTGCCGTCTCACTGGACGGCGCGGGAACCAGAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGGCGCCCGGAACGGTAAGCGGCTGGAACGTCTACCCGACGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAAGC
TATTCTGAGCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9213.76 Da
• Isoelectric Point: 10.7407

>AT172284 WP_215349589.1 NZ_CP061287:900190-900441 [Polynucleobacter sp. MWH-Aus1W21]
MSTQIQNSLDLGRLVRETRKRLKLTQPQLALAANVGVRFIVELEAGKSTLRLENILRVLQALGGVLSVEGMDPFIGNKQD
EVR

Nucleotide

• Length: 252 bp

>AT172284 NZ_CP079713:3889497-3889754 [Salmonella enterica subsp. arizonae]
ATGTATACCACTCGCCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCTGCTGTGCTGAAAACGCTGGCGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCCCGGAAACGGCCCTGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCAAACGCCGAAATAAGCGAAGAGGATCGGGAATGGATTGATGCGCCAGCGGTG
GGCAGGGAGATCCTGTAA