Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1582233..1582857 Replicon chromosome
Accession NZ_CP061285
Organism Polynucleobacter sp. MWH-UH35A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ICV36_RS08310 Protein ID WP_215400237.1
Coordinates 1582453..1582857 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ICV36_RS08305 Protein ID WP_215400236.1
Coordinates 1582233..1582463 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICV36_RS08265 (ICV36_08260) 1577260..1577898 - 639 WP_215400230.1 cytochrome b/b6 domain-containing protein -
ICV36_RS08270 (ICV36_08265) 1577895..1578353 - 459 WP_251374976.1 diheme cytochrome c -
ICV36_RS08275 (ICV36_08270) 1578361..1578738 - 378 WP_215400231.1 DUF1924 domain-containing protein -
ICV36_RS08280 1579511..1580473 - 963 WP_215400232.1 hypothetical protein -
ICV36_RS08285 (ICV36_08285) 1580544..1580942 - 399 WP_215400233.1 hypothetical protein -
ICV36_RS08290 (ICV36_08290) 1580959..1581237 - 279 WP_215400234.1 heavy metal-associated domain-containing protein -
ICV36_RS08295 (ICV36_08295) 1581303..1581917 + 615 WP_215400235.1 Crp/Fnr family transcriptional regulator -
ICV36_RS08305 (ICV36_08305) 1582233..1582463 + 231 WP_215400236.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ICV36_RS08310 (ICV36_08310) 1582453..1582857 + 405 WP_215400237.1 PIN domain-containing protein Toxin
ICV36_RS08315 (ICV36_08315) 1582884..1585460 - 2577 WP_215400238.1 RNA polymerase sigma factor RpoD -
ICV36_RS08320 (ICV36_08320) 1585704..1587671 - 1968 WP_215400239.1 DNA primase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-122)

Antitoxin

SpoVT-AbrB domain

(5-39)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15564.73 Da        Isoelectric Point: 6.9778

>T172282 WP_215400237.1 NZ_CP061285:1582453-1582857 [Polynucleobacter sp. MWH-UH35A]
MNAKKIFFDTNTLLYLLSSDNKKADWVSKNLQHHNVISVQVLNEFTSASLRKIKISNSELDEFLDLFTSTFHVRSLDIDT
FETGLMVSRRYGYQHYDSMIIAAALQAGCERLYSEDMQHRQIIDKRLQIVNPFA

Download         Length: 405 bp

>T172282 NZ_CP079713:2636905-2637189 [Salmonella enterica subsp. arizonae]
ATGACCTATGAGCTGGAGTTTGATCCACGCGCGCTAAAAGAGTGGCAAAAGCTGGGTGAAACGGTAAAAAAACAGTTCCG
CAAGAAACTTGTCGACGTGTTGTCAAATCCGCGGGTTGAGTCTGCGCGGCTGCGTGAACTGCCAGATTGCTACAAAATCA
AGCTGAAGACCTCAGGCTATCGTTTAGTGTATCAGGTGCAGGACGACGTGGTATTGGTGGTGGTGATTGCTATCGGCAAG
AGAGAGAAATCGGCCGTTTATCGCCAGGCAGACAAACGGCTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8976.38 Da        Isoelectric Point: 10.3404

>AT172282 WP_215400236.1 NZ_CP061285:1582233-1582463 [Polynucleobacter sp. MWH-UH35A]
MIVSKWGNSLAIRLPSQVVDYLKLKEGDDIEVHVADKKHFQIKKKPSLQERIEGLRKFRGRMPADFHFDRSELNER

Download         Length: 231 bp

>AT172282 NZ_CP079713:2636673-2636915 [Salmonella enterica subsp. arizonae]
ATGGCCACACTTAACGTCCGTTTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATTACCCC
CACAGAAGCTGTCCGGCTGTTGTTTCAATATGTGGCGGAAAACGGGCGTATGCCTGTTAAAACCGTTACGATTAGCGACA
GCGAAGACACATTGCTACAGACAGTCCGGGAACGACTGGCTAACCCACAGAAAGGAATCAGAGTTAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References