Detailed information of TA system TA172279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1202531..1203120
• Replicon: chromosome
• Accession: NZ_CP061285
• Organism: Polynucleobacter sp. MWH-UH35A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ICV36_RS06280
• Protein ID: WP_215399832.1
• Coordinates: 1202737..1203120 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ICV36_RS06275
• Protein ID: WP_215399831.1
• Coordinates: 1202531..1202740 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICV36_RS06265 (ICV36_06260)	1198699..1201269	+	2571	WP_215399829.1	cyanophycin synthetase	-
ICV36_RS06270 (ICV36_06265)	1201363..1202343	-	981	WP_215401589.1	class 1 fructose-bisphosphatase	-
ICV36_RS06275 (ICV36_06270)	1202531..1202740	+	210	WP_215399831.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
ICV36_RS06280 (ICV36_06275)	1202737..1203120	+	384	WP_215399832.1	type II toxin-antitoxin system VapC family toxin	Toxin
ICV36_RS06285 (ICV36_06280)	1203125..1205734	-	2610	WP_215399834.1	aminopeptidase N	-
ICV36_RS06290 (ICV36_06285)	1205803..1206378	-	576	WP_215399836.1	TMEM165/GDT1 family protein	-
ICV36_RS06295 (ICV36_06290)	1206468..1207586	-	1119	WP_215399837.1	alanine dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-115)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14036.30 Da
• Isoelectric Point: 7.2916

>T172279 WP_215399832.1 NZ_CP061285:1202737-1203120 [Polynucleobacter sp. MWH-UH35A]
MTMVLVDTSVWVAHFRKSNASFESLLINDQILCHPLVLIEIACGSPPAPRSKTLSYIKKLQQAKVATPAETLDFVEKHQL
QESGCGAIDVSLLASTLLSENAQLWTFDKNLEKLAVRLGISYSNKLH

Nucleotide

• Length: 384 bp

>T172279 NZ_CP079713:663225-663328 [Salmonella enterica subsp. arizonae]
GGCAAGGCGACGTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7756.99 Da
• Isoelectric Point: 10.5566

>AT172279 WP_215399831.1 NZ_CP061285:1202531-1202740 [Polynucleobacter sp. MWH-UH35A]
MRTTVTIDDDLYQRGLDLADPEMDKADLFREAINVFIRVQVAKRLAALGGKAPQMKSIPRRKPKSGQQS

Nucleotide

• Length: 210 bp

>AT172279 NZ_CP079713:c663337-663187 [Salmonella enterica subsp. arizonae]
TTTAAAATAAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAA
AGTTGGCATTAATGCAGGCTACGTCGCCTTGCCCTTTAAGAATAGATGACAACGCCAGGTTTTCCAGCTTG