Detailed information of TA system TA172278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 1051333..1051940
• Replicon: chromosome
• Accession: NZ_CP061285
• Organism: Polynucleobacter sp. MWH-UH35A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ICV36_RS05500
• Protein ID: WP_215399624.1
• Coordinates: 1051333..1051623 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: ICV36_RS05505
• Protein ID: WP_215399625.1
• Coordinates: 1051632..1051940 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICV36_RS05485 (ICV36_05475)	1047796..1049181	+	1386	WP_215399621.1	phosphomannomutase/phosphoglucomutase	-
ICV36_RS05490 (ICV36_05480)	1049222..1050349	+	1128	WP_215399622.1	quinolinate synthase NadA	-
ICV36_RS05495 (ICV36_05485)	1050403..1051257	+	855	WP_215399623.1	carboxylating nicotinate-nucleotide diphosphorylase	-
ICV36_RS05500 (ICV36_05490)	1051333..1051623	+	291	WP_215399624.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ICV36_RS05505 (ICV36_05495)	1051632..1051940	+	309	WP_215399625.1	putative addiction module antidote protein	Antitoxin
ICV36_RS05510 (ICV36_05500)	1051948..1053321	-	1374	WP_215399626.1	TAXI family TRAP transporter solute-binding subunit	-
ICV36_RS05515 (ICV36_05505)	1053384..1055042	-	1659	WP_215399627.1	L-aspartate oxidase	-
ICV36_RS05520 (ICV36_05510)	1055164..1055472	-	309	WP_215399628.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (3-96)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11090.01 Da
• Isoelectric Point: 10.5091

>T172278 WP_215399624.1 NZ_CP061285:1051333-1051623 [Polynucleobacter sp. MWH-UH35A]
MHEIRKTEEFKAWLDALNDLMGRAKIQTRIKRLAEGNQGNVKFVGSKVFEMKIDFGPGYRIYYTKQENTVYLLLIGGSKR
TQVKDIQIAKLLAKNL

Nucleotide

• Length: 291 bp

>T172278 NZ_CP079713:342472-342708 [Salmonella enterica subsp. arizonae]
ATCATTGACACGCCGGGACGCAGAATGGTGATCCCGCTGGCCAGAGCCCTCCTGCTGTCAGATAAAGTCTCCCGTGAACT
GTATCCGGTTGTGCATATCGGGGAGGAAAGTTACCGTCTGATGACCACCGACATTCTAATGTCACTTAACCCATTTAGTG
ATGTCACTTTTTCTGGCATGAAGGATCCAATCCTCAGGCCATGGGGACATCAGGATGCTTGTAACCATGTCAGATAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 10960.79 Da
• Isoelectric Point: 9.0889

>AT172278 WP_215399625.1 NZ_CP061285:1051632-1051940 [Polynucleobacter sp. MWH-UH35A]
MKKTITSPYDVAEHLRTPKEMALYLQACIEESNGDAAFIAKALGDIARAKGMAQVANESGLSRESLYKALSGDRIPGFDT
VLKVLTALGLCLHAKPIGKIRT

Nucleotide

• Length: 309 bp

>AT172278 NZ_CP079713:342240-342413 [Salmonella enterica subsp. arizonae]
TTGCTCAAGGCATACGACGTTAATATCTCCAGACTTGTGAGTACGACCATGCAGCACGAAGCCCGTCGTCTGCGTGCGAA
ACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCGAGGTCGCCCTGTTTATTGAAACAAACGGCTCCTTTGCCGATGAAA
ACAGGGACTGGTGA