Detailed information of TA system TA172271

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 994742..995245
• Replicon: chromosome
• Accession: NZ_CP061280
• Organism: Mannheimia bovis strain ZY190616

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ICJ55_RS05085
• Protein ID: WP_188157593.1
• Coordinates: 994742..994987 (-)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ICJ55_RS05090
• Protein ID: WP_188157594.1
• Coordinates: 994997..995245 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICJ55_RS05060	990339..990974	+	636	WP_188157588.1	trimeric intracellular cation channel family protein	-
ICJ55_RS05065	991019..992074	+	1056	WP_188157589.1	electron transport complex subunit RsxD	-
ICJ55_RS05070	992074..992706	+	633	WP_188157590.1	electron transport complex subunit RsxG	-
ICJ55_RS05075	992715..993398	+	684	WP_188157591.1	electron transport complex subunit E	-
ICJ55_RS05080	993658..994614	+	957	WP_188157592.1	lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase	-
ICJ55_RS05085	994742..994987	-	246	WP_188157593.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ICJ55_RS05090	994997..995245	-	249	WP_188157594.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ICJ55_RS05095	995332..996786	-	1455	WP_188157595.1	aminoacyl-histidine dipeptidase	-
ICJ55_RS05100	997001..998302	+	1302	WP_188157596.1	transferrin-binding protein-like solute binding protein	-
ICJ55_RS05105	998426..999835	+	1410	WP_188157597.1	DUF560 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II bacterial toxin-antitoxin system, ParE-like toxin (8-80)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9416.13 Da
• Isoelectric Point: 9.5421

>T172271 WP_188157593.1 NZ_CP061280:c994987-994742 [Mannheimia bovis]
MVYSIKVHEDFVAELNKLDPTIKQQLRKKLDKVVENPHIPKNRLSGELHNCYKIKLRKAGVMLVYQLNDDETCILLLTVG
R

Nucleotide

• Length: 246 bp

>T172271 NZ_CP079712:c143228-142947 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9320.68 Da
• Isoelectric Point: 4.7085

>AT172271 WP_188157594.1 NZ_CP061280:c995245-994997 [Mannheimia bovis]
MANLNIRVDDNVKQQAFLAFDNLGISPSDAIRTFLAYVADTGKMPIKQIIVSDEDAELYNIVKKRLNEPEKIKNTTLYEL
FS

Nucleotide

• Length: 249 bp

>AT172271 NZ_CP079712:c143452-143225 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA