Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 994742..995245 Replicon chromosome
Accession NZ_CP061280
Organism Mannheimia bovis strain ZY190616

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ICJ55_RS05085 Protein ID WP_188157593.1
Coordinates 994742..994987 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ICJ55_RS05090 Protein ID WP_188157594.1
Coordinates 994997..995245 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICJ55_RS05060 990339..990974 + 636 WP_188157588.1 trimeric intracellular cation channel family protein -
ICJ55_RS05065 991019..992074 + 1056 WP_188157589.1 electron transport complex subunit RsxD -
ICJ55_RS05070 992074..992706 + 633 WP_188157590.1 electron transport complex subunit RsxG -
ICJ55_RS05075 992715..993398 + 684 WP_188157591.1 electron transport complex subunit E -
ICJ55_RS05080 993658..994614 + 957 WP_188157592.1 lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase -
ICJ55_RS05085 994742..994987 - 246 WP_188157593.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ICJ55_RS05090 994997..995245 - 249 WP_188157594.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ICJ55_RS05095 995332..996786 - 1455 WP_188157595.1 aminoacyl-histidine dipeptidase -
ICJ55_RS05100 997001..998302 + 1302 WP_188157596.1 transferrin-binding protein-like solute binding protein -
ICJ55_RS05105 998426..999835 + 1410 WP_188157597.1 DUF560 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II bacterial toxin-antitoxin system, ParE-like toxin

(8-80)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9416.13 Da        Isoelectric Point: 9.5421

>T172271 WP_188157593.1 NZ_CP061280:c994987-994742 [Mannheimia bovis]
MVYSIKVHEDFVAELNKLDPTIKQQLRKKLDKVVENPHIPKNRLSGELHNCYKIKLRKAGVMLVYQLNDDETCILLLTVG
R

Download         Length: 246 bp

>T172271 NZ_CP079712:c143228-142947 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9320.68 Da        Isoelectric Point: 4.7085

>AT172271 WP_188157594.1 NZ_CP061280:c995245-994997 [Mannheimia bovis]
MANLNIRVDDNVKQQAFLAFDNLGISPSDAIRTFLAYVADTGKMPIKQIIVSDEDAELYNIVKKRLNEPEKIKNTTLYEL
FS

Download         Length: 249 bp

>AT172271 NZ_CP079712:c143452-143225 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References