Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1595291..1595959 Replicon chromosome
Accession NZ_CP061208
Organism Streptococcus pneumoniae strain D39_P0

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag D39N_RS07900 Protein ID WP_001132285.1
Coordinates 1595780..1595959 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag D39N_RS07895 Protein ID WP_000961810.1
Coordinates 1595291..1595743 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D39N_RS07870 (D39N_01583) 1591181..1591924 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
D39N_RS07875 (D39N_01584) 1591926..1592876 - 951 WP_000451131.1 50S ribosomal protein L11 methyltransferase -
D39N_RS07880 (D39N_01585) 1593014..1593442 - 429 WP_000418176.1 NUDIX hydrolase -
D39N_RS07885 (D39N_01586) 1593408..1594511 - 1104 WP_000719717.1 site-2 protease family protein -
D39N_RS07890 (D39N_01587) 1594530..1595000 - 471 WP_000257105.1 DUF3013 family protein -
D39N_RS07895 (D39N_01588) 1595291..1595743 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
D39N_RS07900 (D39N_01589) 1595780..1595959 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
D39N_RS07905 1596096..1596275 - 180 WP_001809903.1 hypothetical protein -
D39N_RS07910 (D39N_01590) 1596440..1596679 - 240 WP_000818079.1 hypothetical protein -
D39N_RS07915 (D39N_01591) 1596949..1598220 + 1272 WP_001113205.1 replication-associated recombination protein A -
D39N_RS07925 (D39N_01593) 1598767..1600086 - 1320 WP_000608887.1 glycoside hydrolase family 32 protein -
D39N_RS07930 (D39N_01594) 1600096..1600941 - 846 WP_000819520.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T172269 WP_001132285.1 NZ_CP061208:c1595959-1595780 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T172269 NZ_CP079694:c36188-35772 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCCGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT172269 WP_000961810.1 NZ_CP061208:c1595743-1595291 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT172269 NZ_CP079694:c36415-36185 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGAGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References