Detailed information of TA system TA172222

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE(toxin)
• Location: 1547724..1548246
• Replicon: chromosome
• Accession: NZ_CP061202
• Organism: Rhodobacter capsulatus strain A12

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H9N28_RS07205
• Protein ID: WP_055208224.1
• Coordinates: 1547962..1548246 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0N8VGB1
• Locus tag: H9N28_RS07200
• Protein ID: WP_055208226.1
• Coordinates: 1547724..1547972 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9N28_RS07160	1543493..1543996	+	504	WP_055208241.1	hypothetical protein	-
H9N28_RS07165	1543996..1544517	+	522	WP_055208239.1	hypothetical protein	-
H9N28_RS07170	1544888..1545076	+	189	WP_152970434.1	hypothetical protein	-
H9N28_RS07175	1545060..1545302	+	243	WP_055208237.1	hypothetical protein	-
H9N28_RS07180	1545314..1546105	+	792	WP_055208235.1	hypothetical protein	-
H9N28_RS07185	1546108..1546608	+	501	WP_055208233.1	hypothetical protein	-
H9N28_RS07190	1546601..1547092	+	492	WP_074553263.1	hypothetical protein	-
H9N28_RS07195	1547089..1547535	+	447	WP_055208229.1	hypothetical protein	-
H9N28_RS07200	1547724..1547972	+	249	WP_055208226.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H9N28_RS07205	1547962..1548246	+	285	WP_055208224.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H9N28_RS07210	1548259..1548396	+	138	WP_160320005.1	hypothetical protein	-
H9N28_RS07215	1548900..1549154	+	255	WP_111395967.1	hypothetical protein	-
H9N28_RS07220	1549283..1549921	+	639	WP_139182403.1	hypothetical protein	-
H9N28_RS07225	1549870..1550433	+	564	WP_055208219.1	SocA family protein	-
H9N28_RS07230	1550440..1550823	+	384	WP_146707197.1	hypothetical protein	-
H9N28_RS07235	1550953..1551582	-	630	WP_055208217.1	SOS response-associated peptidase	-
H9N28_RS07245	1551993..1553213	-	1221	WP_055208215.1	cysteine desulfurase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1538184..1550823	12639

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10769.48 Da
• Isoelectric Point: 11.0917

>T172222 WP_055208224.1 NZ_CP061202:1547962-1548246 [Rhodobacter capsulatus]
MTYSLEFHESALKEWKALGASVREQFKKKLAERLESPHVPASRLHGAQNRYKIKLRASGHRLVYEVRDAQIVVAVIAVGK
RERNAVYRAAAKRQ

Nucleotide

• Length: 285 bp

>T172222 NZ_CP079668:344926-345294 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8603.78 Da
• Isoelectric Point: 4.2840

>AT172222 WP_055208226.1 NZ_CP061202:1547724-1547972 [Rhodobacter capsulatus]
MANVIHAGVTASVTELKRDPMGTMAAGQGAAVAILNRNQPAFYCVPAAEYEAMVERLEDAELNALADARAGGPFVRVSLD
DL

Nucleotide

• Length: 249 bp

>AT172222 NZ_CP079668:344708-344929 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0N8VGB1