Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/-
Location 40282..40658 Replicon plasmid pLD67-1-165kb
Accession NZ_CP061188
Organism Escherichia coli strain LD67-1

Toxin (Protein)


Gene name parE Uniprot ID A0A075MDK3
Locus tag IB283_RS24975 Protein ID WP_000969988.1
Coordinates 40282..40464 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag IB283_RS24980 Protein ID WP_001324224.1
Coordinates 40461..40658 (-) Length 66 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IB283_RS24965 38281..39315 - 1035 WP_001190234.1 3-deoxy-7-phosphoheptulonate synthase -
IB283_RS24970 39875..40183 - 309 WP_000377483.1 hypothetical protein -
IB283_RS24975 40282..40464 - 183 WP_000969988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IB283_RS24980 40461..40658 - 198 WP_001324224.1 toxin-antitoxin system protein Antitoxin
IB283_RS24985 41340..42614 + 1275 WP_000489609.1 HlyD family secretion protein -
IB283_RS24990 42589..44703 + 2115 WP_001183604.1 peptidase domain-containing ABC transporter -
IB283_RS24995 44873..45184 - 312 WP_001259758.1 colicin V -
IB283_RS25000 45162..45398 - 237 WP_001323890.1 colicin V immunity protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / sitABCD iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA 1..165427 165427


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-112)

Antitoxin

(16-47)


Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6931.07 Da        Isoelectric Point: 4.5349

>T172206 WP_000969988.1 NZ_CP061188:c40464-40282 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Download         Length: 183 bp

>T172206 NZ_CP079645:c5416727-5416344 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7658.53 Da        Isoelectric Point: 7.2046

>AT172206 WP_001324224.1 NZ_CP061188:c40658-40461 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Download         Length: 198 bp

>AT172206 NZ_CP079645:c5416969-5416727 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A075MDK3


Antitoxin

Source ID Structure

References