Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2445272..2445903 Replicon chromosome
Accession NZ_CP061170
Organism Microbacterium sp. HY82

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HCR84_RS11780 Protein ID WP_166980786.1
Coordinates 2445272..2445649 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HCR84_RS11785 Protein ID WP_166980784.1
Coordinates 2445646..2445903 (-) Length 86 a.a.

Genomic Context

HCR84_RS11790HCR84_RS11760HCR84_RS11765HCR84_RS11770HCR84_RS11775HCR84_RS11780HCR84_RS11785HCR84_RS11795HCR84_RS11800
Location: 2445999..2446991 (993 bp)
Type: Others
Protein ID: WP_166980782.1
Location: 2440432..2441334 (903 bp)
Type: Others
Protein ID: WP_166981984.1
Location: 2441367..2442641 (1275 bp)
Type: Others
Protein ID: WP_166980792.1
Location: 2442638..2443138 (501 bp)
Type: Others
Protein ID: WP_195706641.1
Location: 2443299..2445065 (1767 bp)
Type: Others
Protein ID: WP_166980788.1
Location: 2445272..2445649 (378 bp)
Type: Toxin
Protein ID: WP_166980786.1
Location: 2445646..2445903 (258 bp)
Type: Antitoxin
Protein ID: WP_166980784.1
Location: 2447182..2448021 (840 bp)
Type: Others
Protein ID: WP_166980780.1
Location: 2448121..2449404 (1284 bp)
Type: Others
Protein ID: WP_166980778.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HCR84_RS117602440432..2441334-903WP_166981984.1shikimate dehydrogenase-
HCR84_RS117652441367..2442641-1275WP_166980792.1TRAP transporter large permease-
HCR84_RS117702442638..2443138-501WP_195706641.1TRAP transporter small permease subunit-
HCR84_RS117752443299..2445065-1767WP_166980788.1sugar phosphate isomerase/epimerase and 4-hydroxyphenylpyruvate domain-containing protein-
HCR84_RS117802445272..2445649-378WP_166980786.1type II toxin-antitoxin system VapC family toxinToxin
HCR84_RS117852445646..2445903-258WP_166980784.1ribbon-helix-helix protein, CopG familyAntitoxin
HCR84_RS117902445999..2446991+993WP_166980782.1hypothetical protein-
HCR84_RS117952447182..2448021-840WP_166980780.1(S)-ureidoglycine aminohydrolase-
HCR84_RS118002448121..2449404-1284WP_166980778.1aldolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-36)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13601.68 Da        Isoelectric Point: 6.4880

>T172163 WP_166980786.1 NZ_CP061170:c2445649-2445272 [Microbacterium sp. HY82]
MTFVVDTSVLIDVLRGEPAAADALHSARGAGPLHASEVTRLEVLAGMRAPEEVQTRMLFSAVVWHPVDEHIAEIAGILGR
RWLPRNRGIDSADLIIAATAQSLHVSLLTRNVKHFPMFDGLTAPY

Download         Length: 378 bp

>T172163 NZ_CP079631:c14256-13906 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9538.51 Da        Isoelectric Point: 4.8660

>AT172163 WP_166980784.1 NZ_CP061170:c2445903-2445646 [Microbacterium sp. HY82]
MLRTQISLTPEERRLLDEEAARTGRSISALIRDAVSSVYGSQQDADADRRLIEGAFGAWRDRDVDGAEYVERLRSGTRLS
QAAER

Download         Length: 258 bp

>AT172163 NZ_CP079631:c13901-13599 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References