Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 822272..822942 Replicon chromosome
Accession NZ_CP061169
Organism Microbacterium sp. HY60

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HCR76_RS04040 Protein ID WP_166988450.1
Coordinates 822272..822700 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HCR76_RS04045 Protein ID WP_166988452.1
Coordinates 822697..822942 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCR76_RS04025 818415..819686 + 1272 WP_166988448.1 Xaa-Pro peptidase family protein -
HCR76_RS04030 820036..821212 + 1177 Protein_792 DUF3387 domain-containing protein -
HCR76_RS04035 821472..822164 + 693 WP_198248137.1 virulence protein RhuM/Fic/DOC family protein -
HCR76_RS04040 822272..822700 - 429 WP_166988450.1 VapC toxin family PIN domain ribonuclease Toxin
HCR76_RS04045 822697..822942 - 246 WP_166988452.1 hypothetical protein Antitoxin
HCR76_RS04050 822962..823666 - 705 WP_166988454.1 response regulator -
HCR76_RS04055 823656..825476 - 1821 WP_166988456.1 sensor histidine kinase -
HCR76_RS04060 825506..826864 + 1359 WP_166988458.1 cation:dicarboxylase symporter family transporter -
HCR76_RS04065 826957..827388 - 432 WP_166988460.1 PIN domain-containing protein -
HCR76_RS04070 827385..827627 - 243 WP_166988461.1 ribbon-helix-helix protein, CopG family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-139)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16339.57 Da        Isoelectric Point: 6.6434

>T172158 WP_166988450.1 NZ_CP061169:c822700-822272 [Microbacterium sp. HY60]
MKLLDVGVWLAATWGRHVAHPSVRTWFDQQDSELAFCRVTEMGLLRLLSNPSIMREDALTRGATWSVLDRLRADDRVIHL
EEPTNLESVWRTLSARDDTSHKLWTDDYLAAFAQARGLSVVTLDRAFAQRHQSVEVELLVRR

Download         Length: 429 bp

>T172158 NZ_CP079629:c4819131-4818598 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8712.90 Da        Isoelectric Point: 5.0176

>AT172158 WP_166988452.1 NZ_CP061169:c822942-822697 [Microbacterium sp. HY60]
MRTTIDLPDDLLRALKVRAAQRGETLKVVLMRAVSREVAGNTNAHTRVSLPLIAAGAEPTVDVTPDDIATALASDDEQYA
R

Download         Length: 246 bp

>AT172158 NZ_CP079629:c4819408-4819142 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References