Detailed information of TA system TA172158

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 822272..822942
• Replicon: chromosome
• Accession: NZ_CP061169
• Organism: Microbacterium sp. HY60

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HCR76_RS04040
• Protein ID: WP_166988450.1
• Coordinates: 822272..822700 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HCR76_RS04045
• Protein ID: WP_166988452.1
• Coordinates: 822697..822942 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCR76_RS04025	818415..819686	+	1272	WP_166988448.1	Xaa-Pro peptidase family protein	-
HCR76_RS04030	820036..821212	+	1177	Protein_792	DUF3387 domain-containing protein	-
HCR76_RS04035	821472..822164	+	693	WP_198248137.1	virulence protein RhuM/Fic/DOC family protein	-
HCR76_RS04040	822272..822700	-	429	WP_166988450.1	VapC toxin family PIN domain ribonuclease	Toxin
HCR76_RS04045	822697..822942	-	246	WP_166988452.1	hypothetical protein	Antitoxin
HCR76_RS04050	822962..823666	-	705	WP_166988454.1	response regulator	-
HCR76_RS04055	823656..825476	-	1821	WP_166988456.1	sensor histidine kinase	-
HCR76_RS04060	825506..826864	+	1359	WP_166988458.1	cation:dicarboxylase symporter family transporter	-
HCR76_RS04065	826957..827388	-	432	WP_166988460.1	PIN domain-containing protein	-
HCR76_RS04070	827385..827627	-	243	WP_166988461.1	ribbon-helix-helix protein, CopG family	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-139)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 16339.57 Da
• Isoelectric Point: 6.6434

>T172158 WP_166988450.1 NZ_CP061169:c822700-822272 [Microbacterium sp. HY60]
MKLLDVGVWLAATWGRHVAHPSVRTWFDQQDSELAFCRVTEMGLLRLLSNPSIMREDALTRGATWSVLDRLRADDRVIHL
EEPTNLESVWRTLSARDDTSHKLWTDDYLAAFAQARGLSVVTLDRAFAQRHQSVEVELLVRR

Nucleotide

• Length: 429 bp

>T172158 NZ_CP079629:c4819131-4818598 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8712.90 Da
• Isoelectric Point: 5.0176

>AT172158 WP_166988452.1 NZ_CP061169:c822942-822697 [Microbacterium sp. HY60]
MRTTIDLPDDLLRALKVRAAQRGETLKVVLMRAVSREVAGNTNAHTRVSLPLIAAGAEPTVDVTPDDIATALASDDEQYA
R

Nucleotide

• Length: 246 bp

>AT172158 NZ_CP079629:c4819408-4819142 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA