Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 156214..156863 Replicon chromosome
Accession NZ_CP061169
Organism Microbacterium sp. HY60

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HCR76_RS00810 Protein ID WP_166985816.1
Coordinates 156474..156863 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HCR76_RS00805 Protein ID WP_166985818.1
Coordinates 156214..156477 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCR76_RS00780 151587..152543 - 957 WP_166985831.1 thioredoxin domain-containing protein -
HCR76_RS00785 152635..153564 - 930 WP_166985828.1 WYL domain-containing protein -
HCR76_RS00790 153666..154061 + 396 WP_166985826.1 VOC family protein -
HCR76_RS00795 154077..155381 - 1305 WP_166985823.1 hypothetical protein -
HCR76_RS00800 155436..156137 - 702 WP_166985821.1 HAD hydrolase-like protein -
HCR76_RS00805 156214..156477 + 264 WP_166985818.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HCR76_RS00810 156474..156863 + 390 WP_166985816.1 type II toxin-antitoxin system VapC family toxin Toxin
HCR76_RS00815 156875..157459 - 585 WP_166985814.1 hypothetical protein -
HCR76_RS00820 157462..158157 - 696 WP_166985812.1 endonuclease NucS -
HCR76_RS00825 158258..159112 - 855 WP_166985810.1 NmrA family NAD(P)-binding protein -
HCR76_RS00830 159141..160553 - 1413 WP_166985807.1 MFS transporter -
HCR76_RS00835 160703..161395 + 693 WP_166985804.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-50)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13686.58 Da        Isoelectric Point: 5.6263

>T172157 WP_166985816.1 NZ_CP061169:156474-156863 [Microbacterium sp. HY60]
VIYIDTSAVVKTLVSERGSSSVRRLFATSERLVSSRLLAVELNTAAQRRGLPAVHVDETLSRVNLVSVDDDVLDGAIRLQ
SGLRGLDALHLATAILIGDELTVFLAFDPELNAAARRSGLALHPASADG

Download         Length: 390 bp

>T172157 NZ_CP079629:4223300-4223518 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9422.56 Da        Isoelectric Point: 6.3283

>AT172157 WP_166985818.1 NZ_CP061169:156214-156477 [Microbacterium sp. HY60]
MGSVTRTELNQQTARVLARVAAGERVTITDRGRPIAELTPARESGWDALIAAGKVRTATRSGSLTFEPIDLDVSSSDIID
DIRRERG

Download         Length: 264 bp

>AT172157 NZ_CP079629:4222899-4223273 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References